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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Schistosomiasis in pre-school-age children and their mothers in Chikhwawa district, Malawi with notes on characterization of schistosomes and snails
Parasites and Vectors, Volume 7, No. 1, Article 153, Year 2014
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Description
Background: To complement ongoing schistosomiasis control within national control programmes (NCPs) that administer praziquantel to school-age children, assessing the risk and extent of schistosomiasis in pre-school-age children (PSAC) is important. Methods. In June 2012, schistosomiasis in Chikhwawa district, Malawi was assessed across 12 villages examining pre-school-age children (PSAC) and their mothers by serological and parasitological diagnosis, as supplemented with urine-antigen and questionnaire-interview methods. Urinary tract morbidity was inferred by haematuria and albuminuria assays. Results: In total, 49.5% (CI
95
42.6-56.4) of 208 PSAC and 94.5% (CI
95
90.9-98.1) of 165 mothers were seropositive for schistosomiasis, in 2 villages seroprevalence exceeded 75% in PSAC. Egg-patent urogenital and intestinal schistosomiasis was observed; 17.7% (CI
95
12.4-23.2) of PSAC and 45.1% (CI
95
37.4-52.8) of mothers having active schistosomiasis by parasitological and urine-antigen testing combined. PSAC often had extensive daily water contact and many (∼25%) had haematuria and albuminuria. As eggs with an atypical morphology of Schistosoma haematobium were observed, a general selection of schistosome eggs was characterized by DNA barcoding, finding Group I S. haematobium and Group IV and V S. mansoni. Malacological surveys encountered several populations of Bulinus globosus but failed to find Biomphalaria. Conclusions: Both PSAC and their mothers appear to be at significant risk of schistosomiasis and should be considered for treatment within the NCP of Malawi. © 2014 Poole et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Poole, Helen
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Terlouw, Dianne Janette
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Naunje, Andrew W.
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Mzembe, Kondwani
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Stanton, Michelle C.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Betson, Martha E.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Lalloo, David G.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Russell Stothard, John Russell
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 71
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1186/1756-3305-7-153
e-ISSN:
17563305
Research Areas
Environmental
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Malawi