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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Whole-gene analysis of inter-genogroup reassortant rotaviruses from the Dominican Republic: Emergence of equine-like G3 strains and evidence of their reassortment with locally-circulating strains
Virology, Volume 534, Year 2019
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Description
Inter-genogroup reassortant group A rotavirus (RVA) strains possessing a G3 VP7 gene of putative equine origin (EQL-G3) have been detected in humans since 2013. Here we report detection of EQL-G3P[8] RVA strains from the Dominican Republic collected in 2014–16. Whole-gene analysis of RVA in stool specimens revealed 16 EQL-G3P[8] strains, 3 of which appear to have acquired an N1 NSP1 gene from locally-circulating G9P[8] strains and a novel G2P[8] reassortant possessing 7 EQL-G3-associated genes and 3 genes from a locally-circulating G2P[4] strain. Phylogenetic/genetic analyses of VP7 gene sequences revealed nine G3 lineages (I–IX) with newly-assigned lineage IX encompassing all reported human EQL-G3 strains along with the ancestral equine strain. VP1 and NSP2 gene phylogenies suggest that EQL-G3P[8] strains were introduced into the Dominican Republic from Thailand. The emergence of EQL-G3P[8] strains in the Dominican Republic and their reassortment with locally-circulating RVA could have implications for current vaccination strategies. © 2019
Authors & Co-Authors
Katz, Eric M.
United States, Atlanta
Centers for Disease Control and Prevention
Esona, Mathew Dioh
United States, Atlanta
Centers for Disease Control and Prevention
Betrapally, Naga S.
United States, Atlanta
Centers for Disease Control and Prevention
de la Cruz de León, Lucia Aurora
Unknown Affiliation
Rey, Gloria J.
United States, Washington, D.c.
Pan American Health Organization
Bowen, Michael D.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 33
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.virol.2019.06.007
ISSN:
00426822
Research Areas
Genetics And Genomics