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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cationic vesicles based on biocompatible diacyl glycerol-arginine surfactants: Physicochemical properties, antimicrobial activity, encapsulation efficiency and drug release
Colloids and Surfaces B: Biointerfaces, Volume 120, Year 2014
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Description
Physicochemical characteristics of cationic vesicular systems prepared from biocompatible diacyl glycerol-arginine surfactants are investigated. These systems form stable cationic vesicles by themselves and the average diameter of the vesicles decreases as the alkyl chain length of the surfactant increases. The addition of DPPC also modifies the physicochemical properties of these vesicles. Among the drugs these cationic formulations can encapsulate, we have considered Ciprofloxacin and 5-Fluorouracil (5-FU). We show that the percentage of encapsulated drug depends on both the physicochemical properties of the carrier and the type of drug. The capacity of these systems to carry different molecules was evaluated performing in vitro drug release studies. Finally, the antimicrobial activity of empty and Ciprofloxacin-loaded vesicles against Gram-positive and Gram-negative bacteria has been determined. Three bacteria were tested: Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae. The in vitro drug release from all formulations was effectively delayed. Empty cationic vesicles showed antimicrobial activity and Ciprofloxacin-loaded vesicles showed similar or higher antimicrobial activity than the free drug solution. These results suggest that our formulations represent a great innovation in the pharmaceutical field, due to their dual pharmacological function: one related to the nature of the vehiculated drug and the other related to the innate antibacterial properties of the surfactant-based carriers. © 2014 Elsevier B.V.
Authors & Co-Authors
Tavano, L.
Italy, Rende
Università Della Calabria
Pinazo, A.
Spain, Barcelona
Csic - Instituto de Quimica Avanzada de Cataluna Iqac
Abo-Riya, Mohamed A.
Egypt, Benha
Faculty of Science
Infante, María Rosa
Spain, Barcelona
Csic - Instituto de Quimica Avanzada de Cataluna Iqac
Manresa, A.
Spain, Barcelona
Universitat de Barcelona
Muzzalupo, R.
Italy, Rende
Università Della Calabria
Pérez, Lourdes
Spain, Barcelona
Csic - Instituto de Quimica Avanzada de Cataluna Iqac
Statistics
Citations: 41
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.colsurfb.2014.04.009
ISSN:
09277765
e-ISSN:
18734367