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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Risk factors for thrombosis in an african population
Clinical Medicine Insights: Blood Disorders, Volume 7, Year 2014
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Description
Little is known about the biological, epidemiological, and clinical risk factors for thrombosis and venous thromboembolism (VTE) among Black Africans. We undertook a study of the prevalence of VTE risk factors for thrombosis in a Senegalese population. A three-year cross-sectional and case-control study involving 105 cases and 200 controls was conducted in various hospitals in Dakar (Senegal). Our results demonstrate that oral contraception, immobilization by casts, surgery, and blood group were significantly associated with VTE occurrence. Additionally, 16 cases and 2 controls had protein S (PS) values of less than 48.4% (M-2SD), exhibiting a highly significant difference (P < 1 × 10-4). The number of cases with a low protein C (PC) level was significantly higher than the respective number of controls. Using logistic regression methods, we established a correlation between significantly associated variables and deep venous thrombosis (DVT) occurrence. Age, obesity, sickle cell disease, and PC deficiency were not significantly associated with thrombosis. In contrast, gender, PS deficiency, varicose veins, surgery, non-O blood type, and the presence of antiphospholipid antibodies were significantly and independently associated with DVT. These findings are extremely useful for clinical management of patients suffering from DVT and can help to reduce the high recurrence rate observed in our study. © the authors, publisher and licensee Libertas Academica Limited.
Authors & Co-Authors
Fall, Awa Oumar Touré
Senegal, Fann
Cheikh Anta Diop University of Dakar
Proulle, Valérie
France, Le Kremlin-bicetre
Hopital de Bicetre
Sall, Abibatou F.
Senegal, Fann
Cheikh Anta Diop University of Dakar
Mbaye, Alassane D.
Senegal
Grand Yoff Hospital of Dakar
Ba, Pape Samba
Senegal, Dakar
Principal Hospital
Diao, Maboury L.
Senegal
Aristide le Dantec Hospital of Dakar
Seck, Moussa T.
Senegal, Fann
Cheikh Anta Diop University of Dakar
Gadji, Macoura
Senegal, Fann
Cheikh Anta Diop University of Dakar
Gning, Sarah Boury
Senegal, Dakar
Principal Hospital
Diop, Saliou N.
Senegal, Fann
Cheikh Anta Diop University of Dakar
Diéye, Tandakha Ndiaye D.
Senegal, Fann
Cheikh Anta Diop University of Dakar
Faye, Babacar Félix
Senegal, Fann
Cheikh Anta Diop University of Dakar
Thiam, Doudou
Senegal, Fann
Cheikh Anta Diop University of Dakar
Dreyfus, Marie D.
France, Le Kremlin-bicetre
Hopital de Bicetre
Statistics
Citations: 17
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.4137/CMBD.S13401
e-ISSN:
1179545X
Research Areas
Health System And Policy
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Senegal