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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Quantitative analysis of HIV-1 variants with the K103N resistance mutation after single-dose nevirapine in women with HIV-1 subtypes A, C, and D
Journal of Acquired Immune Deficiency Syndromes, Volume 42, No. 5, Year 2006
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Description
INTRODUCTION: We used a sensitive point mutation assay, LigAmp, to detect and quantify K103N-containing variants in African women who received single-dose nevirapine (NVP) to prevent mother-to-child HIV-1 transmission. METHODS: Plasma for testing was collected 6 to 8 weeks postpartum from 301 women (144 subtype A, 63 subtype C, and 94 subtype D). RESULTS: The portion of women with 0.5% or more K103N-containing variants was lowest for subtype A (60/144, 41.7%) and highest for subtype C (44/63, 69.8%; P < 0.0001). K103N was rarely detected in pre-NVP samples. In a multivariate model, K103N detection was associated with HIV-1 subtype (C > A), after adjusting for log10 delivery viral load, the number of days between NVP dosing and sample collection, age, and parity. Among women with K103N detected: (1) the median %K103N was lower for subtype A (2.2%) than C (11.7%, P = 0.0001) or D (5.5%, P = 0.04), and (2) in a multivariate linear model, higher log10 (%K103N) was associated with HIV subtype (C > A, P = 0.0001; D > A, P = 0.01; and C vs D, no difference), but not other factors. CONCLUSIONS: After administration of single-dose NVP, K103N was detected more frequently and at higher levels in women with subtypes C and D than A. Further studies are needed to evaluate the clinical significance of NVP-resistant variants in this setting. Copyright © 2006 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Flys, Tamara S.
United States, Baltimore
Johns Hopkins School of Medicine
Chen, Shu
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Jones, Dana C.
United States, Baltimore
Johns Hopkins School of Medicine
Hoover, Donald R.
United States, New Brunswick
Institute for Health, Health Care Policy and Aging Research
Church, Jessica D.
United States, Baltimore
Johns Hopkins School of Medicine
Fiscus, Susan A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Mwatha, Anthony K.
United States, Seattle
Fred Hutchinson Cancer Research Center
Guay, Laura A.
United States, Baltimore
Johns Hopkins School of Medicine
Mmiro, Francis A.
United States, Seattle
Fred Hutchinson Cancer Research Center
Uganda, Kampala
Makerere University
Musoke, Philippa Martha
Uganda, Kampala
Makerere University
Kumwenda, Newton I.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Taha, Taha E.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Jackson, J. Brooks
United States, Baltimore
Johns Hopkins School of Medicine
Eshleman, Susan H.
United States, Baltimore
Johns Hopkins School of Medicine
United States, Baltimore
Johns Hopkins Medical Institutions
Statistics
Citations: 90
Authors: 14
Affiliations: 7
Identifiers
Doi:
10.1097/01.qai.0000221686.67810.20
ISSN:
15254135
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Study Approach
Quantitative
Participants Gender
Female