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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genetic variation of innate immune genes in HIV-infected African patients with or without oropharyngeal candidiasis
Journal of Acquired Immune Deficiency Syndromes, Volume 55, No. 1, Year 2010
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Description
Background: The occurrence of oropharyngeal candidiasis (OPC) in combination with HIV disease progression is a very common phenomenon. However, not all HIV-infected patients develop OPC, even when they progress to low CD4 + T-cell counts. Because T-cell immunity is defective in AIDS, the innate defence mechanisms are likely to have a central role in antifungal immunity in these patients. We investigated whether genetic variations in the innate immune genes DECTIN-1, TLR2, TLR4, TIRAP, and CASPASE-12 are associated with the presence of OPC in HIV-infected subjects from East Africa. Methods: A total of 225 HIV patients were genotyped for several single nucleotide polymorphisms (SNPs), and this was correlated with the occurrence of OPC in these patients. In addition, primary immune cells obtained from individuals with different genotypes were stimulated with Candida albicans, and cytokine production was measured. Results: The analysis revealed that no significant differences in the polymorphism frequencies could be observed, although a tendency toward a protective effect on OPC of the DECTIN-1 I223S SNP was apparent. Furthermore, interferon γ production capacity was markedly lower in cells bearing the DECTIN-1 SNP I223S. It could also be demonstrated that the 223S mutated form of the DECTIN-1 gene exhibits a lower capacity to bind zymosan. Conclusions: These data demonstrate that common polymorphisms of TLR2, TLR4, TIRAP, and CASPASE-12 do not influence susceptibility to OPC in HIV-infected patients in East Africa but suggest an immunomodulatory effect of the I223S SNP on dectin-1 function and possibly the susceptibility to OPC in HIV patients. Copyright © 2010 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Plantinga, Theo S.
Netherlands, Nijmegen
Radboud University Medical Center
Hamza, Omar J.M.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Willment, Janet Anne
South Africa, Cape Town
University of Cape Town
Ferwerda, Bart
Netherlands, Nijmegen
Radboud University Medical Center
Van De Geer, Nicole M.D.
Netherlands, Nijmegen
Radboud University Medical Center
Verweij, Paul E.
Netherlands, Nijmegen
Radboud University Medical Center
Matee, Mecky Isaac N.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Banahan, Kathy
Ireland, Dublin
Trinity College Dublin
O'Neill, Luke A.J.
Ireland, Dublin
Trinity College Dublin
Kullberg, Bart Jan
Netherlands, Nijmegen
Radboud University Medical Center
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
van der Ven, André J.A.M.
Netherlands, Nijmegen
Radboud University Medical Center
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Statistics
Citations: 43
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1097/QAI.0b013e3181e53c64
ISSN:
15254135
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries