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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
No difference in keratin thickness between inner and outer foreskins from elective male circumcisions in Rakai, Uganda
PLoS ONE, Volume 7, No. 7, Article e41271, Year 2012
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Description
It has been hypothesized that increased HIV acquisition in uncircumcised men may relate to a more thinly keratinized inner foreskin. However, published data are contradictory and potentially confounded by medical indications for circumcision. We tested the hypothesis that the inner foreskin was more thinly keratinized than the outer foreskin using tissues from 19 healthy, HIV-uninfected men undergoing routine prophylactic circumcision in Rakai, Uganda. Sections from 3 foreskin anatomic sites (inner, outer, and frenar band) were snap-frozen separately. Two independent laboratories each separately stained, imaged, and measured keratin thicknesses in a blinded fashion. There was no significant difference in keratin thickness between the inner (mean = 14.67±7.48 μm) and outer (mean = 13.30±8.49 μm) foreskin, or between the inner foreskin and the frenar band (mean = 16.91±12.42 μm). While the frenar band showed the greatest intra-individual heterogeneity in keratin thickness, there was substantial inter-individual variation seen in all regions. Measurements made by the two laboratories showed high correlation (r = 0.741, 95% CI, 0.533-0.864). We conclude that, despite inter- and intra-individual variability, keratin thickness was similar in the inner and outer foreskin of healthy Ugandan men, and that reduced keratin thickness is not likely to make the inner foreskin more susceptible to HIV acquisition. © 2012 Dinh et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3399815/bin/pone.0041271.s001.tif
Authors & Co-Authors
Dinh, Minh H.
United States, Chicago
Northwestern University Feinberg School of Medicine
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Hirbod, Taha
Sweden, Stockholm
Karolinska Institutet
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Kigozi, Godfrey G.
Uganda, Kalisizo
Rakai Health Sciences Program
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Okocha, Eneniziaogochukwu A.
United States, Chicago
Northwestern University Feinberg School of Medicine
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Cianci, Gianguido C.
United States, Chicago
Northwestern University Feinberg School of Medicine
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Kong, Xiangrong
Uganda, Kampala
Makerere University
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Prodger, Jessica L.
Canada, Toronto
University of Toronto
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Broliden, Kristina
Sweden, Stockholm
Karolinska Institutet
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Kaul, Rupert
Canada, Toronto
University of Toronto
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Serwadda, David Musoke
Uganda, Kampala
Makerere University
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Wawer, Maria J.
Canada, Toronto
University of Toronto
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gray, Ronald H.
Canada, Toronto
University of Toronto
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Hope, Thomas John
United States, Chicago
Northwestern University Feinberg School of Medicine
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 26
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0041271
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Uganda
Participants Gender
Male