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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Antioxidant and antitumor activities of Artemisia campestris and Thymelaea hirsuta from southern Tunisia
Food and Chemical Toxicology, Volume 49, No. 2, Year 2011
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Description
The essential oil of Artemisia campestris and the ethanol-water, hexane and water extracts of A. campestris and Thymelaea hirsuta collected in southern of Tunisia were investigated for their antioxidant (DPPH, ABTS and beta-carotene methods) and antitumor growth inhibition of human colon cancer HT-29 cells using MTT test activities. All the A. campestris extracts tested at high concentrations (100 μg/ml) showed activity ranging from 19.5% for essential oil to 64.4% of negative control growth for infusion extract, except the hexane extract. With T. hirsuta, all the extracts tested (hexane and ethanol-water), except the infusion extract, also exhibited antitumor activity (58.2% and 65.5% of control growth respectively). The ethanol-water and infusion extracts of A. campestris showed higher antioxidant activity, polyphenol and flavonoid contents than those of T. hirsuta. These results show that there is a positive correlation between the antitumor activity and the antioxidant activity, and of these two activities and with the levels of polyphenols and flavonoids. The essential oil and the other extracts of A. campestris, which exhibited significant antitumor activity against the HT-29 cells deserve further research into the chemoprevention and treatment of colon cancer. © 2010 Elsevier Ltd.
Authors & Co-Authors
Akrout, Ahmed A.
Tunisia, Medenine
Institut Des Régions Arides
Gonzalez, Lidia Alarcon
Spain, Almeria
Universidad de Almería
El-Jani, Hajer
Tunisia, Medenine
Institut Des Régions Arides
Madrid, Pablo Campra
Spain, Almeria
Universidad de Almería
Statistics
Citations: 170
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.fct.2010.11.003
ISSN:
02786915
Research Areas
Cancer
Environmental
Study Locations
Tunisia