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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Reproducibility of liver stiffness measurements in hepatitis C virus (HCV)-infected patients in Egypt
Journal of Viral Hepatitis, Volume 18, No. 7, Year 2011
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Description
Elastometry has demonstrated good accuracy, but little is known about its reproducibility. The aim of this study was to assess the intra- and inter-operator reproducibility of liver stiffness measurement among hepatitis C virus (HCV)-infected patients in Egypt. The study was conducted among HCV-infected patients referred for treatment evaluation in two hepatitis treatment centres of Cairo. Two operators took liver stiffness measurement two times per patient the same day. Intra- and inter-reproducibility were estimated by different methods: Bland and Altman graphics, variation coefficient, intraclass correlation coefficient and Kappa coefficient; 7.1 kPa was used as the threshold of significant (≥F2) fibrosis whenever needed. Fifty-eight patients were included in the study, and 216 measurements were taken. Failure rate was 7% and associated with overweight. For a value of 7.1 kPa, the inter-operator 95% limits of agreement were estimated at ±2.88 kPa. Intra- and inter-operator coefficients of variation ranged between 11% and 15%, intraclass correlation coefficients [95% confidence interval] between 0.94 [0.86-0.97] and 0.97 [0.95-0.99], and Kappa coefficients between 0.65 [0.44-0.88] and 0.92 [0.81-1.00]. The reliability of liver stiffness measurement is questionable when considering the decision to initiate antiviral therapy because of the percentage of discordance between measurements is notable, especially in the intermediate fibrosis stages. © 2011 Blackwell Publishing Ltd.
Authors & Co-Authors
Vignier, Nicolas
France, Paris
Institut Pasteur, Paris
Esmat, Gamal
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Cairo
Faculty of Medicine
Elsharkawy, Aisha
Egypt, Cairo
Faculty of Medicine
Hassany, Mohamed
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Bonnard, P.
France, Paris
Hôpital Tenon
Delarocque-Astagneau, Elisabeth
France, Paris
Institut Pasteur, Paris
Said, Mohamed
Egypt, Cairo
Cairo University Hospitals
Raafat, R.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
El-Hoseiny, Mostafa M.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Fontanet, A. L.
France, Paris
Institut Pasteur, Paris
Mohamed, Mostafa K.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Vray, Muriel M.
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Statistics
Citations: 16
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1111/j.1365-2893.2010.01433.x
ISSN:
13520504
e-ISSN:
13652893
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Egypt