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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effective connectivity of the posterior cingulate and medial prefrontal cortices relates to working memory impairment in schizophrenic and bipolar patients
Schizophrenia Research, Volume 158, No. 1-3, Year 2014
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Description
Background: Schizophrenia (SZ) and bipolar I disorder (BD) share many overlapping clinical features, confounding the current diagnostic systems. Recent studies suggest the posterior cingulate (PCC) and medial prefrontal (MPFC) cortices that are involved in SZ and BD pathophysiology. However, the roles of PCC and MPFC in providing specific distinctive and shared neural substrates between these two disorders remain largely unknown. Examining the neurophysiologic mechanism of these diseases may help explain the clinical observations and differentiate the two disorders. Methods: We used the Dynamic Casual Modeling (DCM), which is capable of eliciting hidden neuronal dynamics and reveal cross-regulation of multiple neuronal systems, to characterize the pattern of disrupted effective connectivity in the left PCC-MPFC circuit during working memory tasks in 36 SZ and 20 BD patients as well as 29 healthy controls. Results: Compared to the healthy controls, both SZ and BD patient groups exhibited significant negative effective connectivity from the left MPFC to PCC. The negative effective connectivity was more remarkable in schizophrenic patients. Only patients with BD differed from healthy controls with positive effective connectivity from the left PCC to MPFC. Conclusions: Whole brain analysis revealed deactivation of the left PCC and MPFC across all patient groups. This study provides new insight that changes in effective connectivity of the left MPFC to left PCC circuit during working memory processing may be a core pathophysiological feature distinguishing SZ from BD. © 2014 Elsevier B.V.
Authors & Co-Authors
Wu, Guowei
China, Changsha
Second Xiangya Hospital of Central South University
Wang, Yunxia
China, Beijing
Institute of High Energy Physics, Chinese Academy of Sciences
China, Beijing
Institute of Automation Chinese Academy of Sciences
Mwansisya, Tumbwene Elieza
China, Changsha
Second Xiangya Hospital of Central South University
Tanzania, Dodoma
The University of Dodoma
Pu, Weidan
China, Changsha
Second Xiangya Hospital of Central South University
Zhang, Huiran
China, Changsha
Second Xiangya Hospital of Central South University
Liu, Chang
China, Changsha
Second Xiangya Hospital of Central South University
Yang, Qing
United States, New Haven
Yale School of Medicine
Chen, Eric Yu Hai
Hong Kong, Hong Kong
The University of Hong Kong
Xue, Zhimin
China, Changsha
Second Xiangya Hospital of Central South University
Liu, Zhening
China, Changsha
Second Xiangya Hospital of Central South University
China, Changsha
Central South University
Shan, Baoci
China, Beijing
Institute of High Energy Physics, Chinese Academy of Sciences
China, Beijing
Beijing Engineering Research Center of Radiographic Techniques and Equipment
Statistics
Citations: 38
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1016/j.schres.2014.06.033
ISSN:
09209964
e-ISSN:
15732509
Research Areas
Health System And Policy
Mental Health