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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Virulence evolution in response to vaccination: The case of malaria
Vaccine, Volume 26, No. SUPPL. 3, Year 2008
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Description
One theory of why some pathogens are virulent (i.e., they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and this resource extraction can damage the host. Here we describe our studies in malaria that test and support this idea. We go on to show that host immunity can exacerbate selection for virulence and therefore that vaccines that reduce pathogen replication may select for more virulent pathogens, eroding the benefits of vaccination and putting the unvaccinated at greater risk. We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered. © 2008 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
MacKinnon, Margaret J.
United Kingdom, Cambridge
University of Cambridge
Kenya, Kilifi
Kemri-wellcome Trust Collaborative Research Programme
Gandon, Sylvain
France, Montpellier
Ird Centre de Montpellier
France, Montpellier
Centre D’ecologie Fonctionnelle et Evolutive
Read, Andrew F.
United States, University Park
Center for Infectious Disease Dynamics
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 69
Authors: 3
Affiliations: 6
Identifiers
Doi:
10.1016/j.vaccine.2008.04.012
ISSN:
0264410X
Research Areas
Infectious Diseases