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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Long-term survival after Edmonston-Zagreb measles vaccination in Guinea-Bissau: Increased female mortality rate
Journal of Pediatrics, Volume 122, No. 6, Year 1993
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Description
In an urban area of Guinea-Bissau, 384 children were enrolled in a randomized trial comparing morbidity and mortality rates atter receiving high-tirer Edmonston-Zagreb (EZ) measles vaccine administered from 4 months of age, with a control group receiving inactivated poliomyelitis vaccine at 4 months of age and the standard Schwarz vaccine from 9 months of age. Children were followed to the age of at least 3 years. The mortality ratio of the EZ vaccinees compared with control subjects was 1.79 (range, 1.06 to 3.02; p = 0.027) if children were excluded at the time of migration; if deaths after migration were included, the mortality ratio was 1.53 (range, 0.94 to 2.49; p = 0.087). Girls in the EZ group had significantly higher mortality rates than girls in the control group (mortality ratio = 1.95; range, 1.07 to 3.56; p = 0.027); there was no difference for the boys (mortality ratio = 0.98; range, 0.41 to 2.30). Adjustment for background factors in a Cox regression model did not modify these estimates. Furthermore, female recipients of EZ vaccine had more days with diarrhea (relative risk = 1.35; range, 1.17 to 1.56; p = 0.00003) and were more likely than control subjects to visit a health center in the month after vaccination (relative risk = 1.86; range, 1.05 to 3.31; p = 0.027); those who consulted were more likely to die subsequently (mortality ratio = 2.31; range, 0.99 to 5.41; p = 0.054). These observations were unplanned and require confirmation in larger studies. © 1993, Mosby-Year Book, Inc. All right reserved. All rights reserved.
Authors & Co-Authors
Aaby, Peter
Denmark, Copenhagen
Statens Serum Institut
Knudsen, Kim Mark
Denmark, Copenhagen
Statens Serum Institut
Whittle, Hilton C.
Denmark, Copenhagen
Statens Serum Institut
Lisse, Ida Maria
Denmark, Copenhagen
Statens Serum Institut
Poulsen, Anja Grethe
Denmark, Copenhagen
Statens Serum Institut
Sodemann, Morten
Denmark, Copenhagen
Statens Serum Institut
Jakobsen, Marianne Skytte
Denmark, Copenhagen
Statens Serum Institut
Brink, Lene
Denmark, Copenhagen
Statens Serum Institut
Gansted, Uffe
Denmark, Copenhagen
Statens Serum Institut
Permin, Astrid
Denmark, Copenhagen
Statens Serum Institut
Jensen, Thøger Gorm
Denmark, Copenhagen
Statens Serum Institut
Andersen, Henning
Denmark, Copenhagen
Statens Serum Institut
Silva, Maria Clotilde Da
Denmark, Copenhagen
Statens Serum Institut
Statistics
Citations: 125
Authors: 13
Affiliations: 1
Identifiers
Doi:
10.1016/S0022-3476(09)90015-4
ISSN:
00223476
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Study Locations
Guinea
Guinea-Bissau
Participants Gender
Male
Female