Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Low incidence of renal dysfunction among HIV-infected patients on a tenofovir-based first line antiretroviral treatment regimen in Myanmar
PLoS ONE, Volume 10, No. 8, Article e0135188, Year 2015
Notification
URL copied to clipboard!
Description
Background Since 2004, Médecins Sans Frontières-Switzerland has provided treatment and care for people living with HIV in Dawei, Myanmar. Renal function is routinely monitored in patients on tenofovir (TDF)-based antiretroviral treatment (ART), and this provides an opportunity to measure incidence and risk factors for renal dysfunction. Methods We used routinely collected program data on all patients aged ≥15 years starting first-line TDF-based ART between January 2012 and December 2013. Creatinine clearance (CrCl) was assessed at base line and six-monthly, with renal dysfunction defined as CrCl < 50ml/min/1.73m2.We calculated incidence of renal dysfunction and used Cox regression analysis to identify associated risk factors. Results There were 1391 patients, of whom 1372 had normal renal function at baseline. Of these, 86 (6.3%) developed renal dysfunction during a median time of follow-up 1.14 years with an incidence rate of 5.4 per 100 person-years: 78 had CrCl between 30-50ml/min/1.73m2 and were maintained on TDF-based ART, but 5 were changed to another regimen: 4 because of CrCl <30ml/min/1.73m2. Risk factors for renal dysfunction included age ≥45 years, diagnosed diabetes, underlying renal disease, underweight and CD4 count <200cells/mm3. There were 19 patients with baseline renal dysfunction and all continued on TDF-based ART: CrCl stayed between 30-49 ml/min/1.73m2 in five patients while the remainder regained normal renal function. Conclusions In a resource-poor country like Myanmar, the low incidence of renal toxicity in our patient cohort suggests that routine assessment of CrCl may not be needed and could be targeted to high risk groups if resources permit. Copyright: © 2015 Kyaw et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4547764/bin/pone.0135188.s001.xlsx
Authors & Co-Authors
Harries, Anthony David
France, Paris
International Union Against Tuberculosis and Lung Disease
United Kingdom, London
London School of Hygiene & Tropical Medicine
Chinnakali, Palanivel
India, Puducherry
Jawaharlal Institute of Postgraduate Medical Education and Research
Antierens, Annick
Belgium, Brussels
Medecins Sans Frontieres, Brussels
Das, Mrinalini
Switzerland, Geneva
Medecins Sans Frontieres
Shetty, Sharmila S.
Switzerland, Geneva
Medecins Sans Frontieres
Statistics
Citations: 16
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0135188
ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative