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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Insulin response in relation to insulin sensitivity: An appropriate β-cell response in black South African women
Diabetes Care, Volume 32, No. 5, Year 2009
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Description
OBJECTIVE - The purpose of this study was to characterize differences in the acute insulin response to glucose (AIRg) relative to insulin sensitivity (SI) in black and white premenopausal normoglycemic South African women matched for body fatness. RESEARCH DESIGN AND METHODS - Cross-sectional analysis including 57 black and white South African women matched for BMI, SI, AIRg, and the disposition index (AIRg X SI) were performed using a frequently sampled intravenous glucose tolerance test with minimal model analysis, and similar measures were analyzed using an oral glucose tolerance test (OGTT). Body composition was assessed by dual-energy X-ray absorptiometry and computed tomography. RESULTS - SI was significantly lower (4.4 ± 0.8 vs. 9.4 ± 0.8 and 2.9 ± 0.8 vs. 6.0 ± 0. 8 × 10 -5 min-1/[pmol/l], P < 0.001) and AIRg was significantly higher (1,028 ± 255 vs. 352 ± 246 and 1,968 ± 229 vs. 469 ± 246 pmol/l, P < 0.001), despite similar body fatness (30.9 ± 1.4 vs. 29.7 ± 1.3 and 46.8 ± 1.2 vs. 44.4 ± 1.3%) in the normal-weight and obese black women compared with their white counterparts, respectively. Disposition index, a marker of β-cell function, was not different between ethnic groups (3,811 ± 538 vs. 2,966 ± 518 and 3,646 ± 485 vs. 2,353 ± 518 × 10-5 min, P = 0.10). Similar results were obtained for the OGTT-derived measures. CONCLUSIONS - Black South African women are more insulin resistant than their white counterparts but compensate by increasing their insulin response to maintain normal glucose levels, suggesting an appropriate β-cell response for the level of insulin sensitivity. © 2009 by the American Diabetes Association.
Authors & Co-Authors
Goedecke, Julia H.
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
South African Medical Research Council
United Kingdom, Edinburgh
Edinburgh Medical School
Dave, Joel A.
South Africa, Cape Town
University of Cape Town
Faulenbach, Mirjam V.
United States, Seattle
University of Washington
Utzschneider, Kristina M.
United States, Seattle
University of Washington
Lambert, E. Victoria
South Africa, Cape Town
University of Cape Town
West, Sacha J.
South Africa, Cape Town
University of Cape Town
Collins, Malcolm R.
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
South African Medical Research Council
Olsson, Tommy
Sweden, Umea
Umeå Universitet
Walker, Brian Robert
United Kingdom, Edinburgh
Edinburgh Medical School
Seckl, Jonathan R.
United Kingdom, Edinburgh
Edinburgh Medical School
Kahn, Steven E.
United States, Seattle
University of Washington
Levitt, Naomi S.
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 80
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.2337/dc08-2048
ISSN:
01495992
e-ISSN:
19355548
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Female