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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Influence of the AGTR1 A1166C genotype on the progression of arterial stiffness: A 16-year longitudinal study
American Journal of Hypertension, Volume 26, No. 12, Year 2013
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Description
Background We examined the influence of the AGTR1 A1166C genotype on the 16-year evolution of pulse wave velocity (PWV) in a middle-aged population. In a cross-sectional study, we reported that the presence of the AGTR1 1166C allele was associated with higher aortic stiffness compared with the AGTR1 1166AA genotype. methods The study was conducted in 259 subjects who underwent 3 health check-ups over 16 years at the Centre IPC-Paris: an initial visit in 1992-1993, an intermediate visit in 1998-1999, and a final visit in 2007-2008. Aortic stiffness was assessed during the 3 visits by measuring carotid-femoral PWV. AGTR1 A1166C polymorphism was assayed by allele-specific oligonucleotide hybridization. results AGTR1 1166C allele carriers (AC + CC genotypes) had a 35% more pronounced increase in PWV over this 16-year period when compared with the AGTR1 1166AA subjects (3.01 ± 0.32 vs. 1.92 ± 0.23 m/s; P < 0.001). This increase remained significant after adjustment for age, sex, initial PWV values, and changes in blood pressure (+37%; P < 0.05). The genotype-related differences in PWV were only observed at the last visit (i.e., later in life, after the age of 55 years). The effects of this genotype on PWV were not related to the presence of antihypertensive treatment. conclusions This is the first long-term longitudinal study indicating that AT1 1166C carriers are at increased risk of pronounced arterial stiffening during aging especially after the age of 55. © American Journal of Hypertension, Ltd 2013.
Authors & Co-Authors
Bénétos, Athanase M.
France, Nancy
Chu de Nancy
France, Nancy
Université de Lorraine
Giron, Alain
France, Paris
Inserm
Joly, Laure
France, Nancy
Chu de Nancy
France, Nancy
Université de Lorraine
Temmar, Mohamed M.
France, Paris
Investigations Préventives et Cliniques Center
Algeria
Telomere Center Blida
Nzietchueng, Rosine Mayap
France, Nancy
Chu de Nancy
France, Nancy
Université de Lorraine
Pannier, Bruno M.
France, Paris
Investigations Préventives et Cliniques Center
France
Manhes Hospital
Bean, Kathryn E.
France, Paris
Investigations Préventives et Cliniques Center
Thomas, Frédérique
France, Paris
Investigations Préventives et Cliniques Center
Labat, Carios
France, Nancy
Université de Lorraine
Lacolley, Patrick J.
France, Nancy
Université de Lorraine
France, Nancy
Chu de Nancy
Statistics
Citations: 15
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1093/ajh/hpt141
ISSN:
08957061
e-ISSN:
19417225
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative