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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Nature Medicine, Volume 26, No. 5, Year 2020
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Description
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
Authors & Co-Authors
Bécavin, Christophe
France, Valbonne
Institut de Pharmacologie Moléculaire et Cellulaire
Queen, Rachel A.
United Kingdom, Newcastle
Newcastle University
Litviňuková, Monika
Germany, Berlin
Helmholtz Association of German Research Centres
United Kingdom, Hinxton
Wellcome Sanger Institute
Talavera-Lopez, Carlos N.
United Kingdom, Hinxton
Wellcome Sanger Institute
Maatz, Henrike
Germany, Berlin
Helmholtz Association of German Research Centres
Reichart, Daniel E.
United States, Boston
Harvard Medical School
Banovich, Nicholas E.
United States, Phoenix
Translational Genomics Research Institute
Barbry, Pascal J.P.
France, Valbonne
Institut de Pharmacologie Moléculaire et Cellulaire
Brazma, A. N.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Collin, Joseph F.
United Kingdom, Newcastle
Newcastle University
Desai, Tushar J.
United States, Stanford
Stanford University School of Medicine
Duong, Thu Elizabeth
United States, La Jolla
University of California, San Diego
United States, San Diego
Rady Children's Hospital
Eickelberg, Oliver
United States, Aurora
University of Colorado Anschutz Medical Campus
Falk, Christine Susanne
Germany, Hannover
Hannover Medical School
Farzan, Michael R.
Unknown Affiliation
Glass, Ian A.
United States, Seattle
University of Washington
Gupta, Ravindra K.
United Kingdom, Cambridge
University of Cambridge
Haniffa, Muzlifah A.
United Kingdom, Newcastle
Newcastle University
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Horváth, Ṕeter
Hungary, Szeged
Szegedi Biológiai Kutatóközpontjának
Finland, Helsinki
Helsingin Yliopisto
Hung, Deborah T.
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Massachusetts Institute of Technology
Kaminski, Naftali
United States, New Haven
Yale School of Medicine
Krasnow, Mark A.
United States, Chevy Chase
Howard Hughes Medical Institute
Kropski, Jonathan A.
United States, Nashville
Vanderbilt University Medical Center
United States
Va Medical Center
United States, Nashville
Vanderbilt University
Kühnemund, Malte
Unknown Affiliation
Lako, Majlinda
United Kingdom, Newcastle
Newcastle University
Lee, Hae-ock
South Korea, Bucheon-si
The Catholic University of Korea
Leroy, Sylvie
France, Valbonne
Institut de Pharmacologie Moléculaire et Cellulaire
Linnarson, Sten
Sweden, Stockholm
Karolinska Institutet
Lundeberg, Joakim
Sweden, Stockholm
Stockholms Universitet
Meyer, Kerstin B.
United Kingdom, Hinxton
Wellcome Sanger Institute
Misharin, Alexander V.
United States, Evanston
Northwestern University
Nawijn, Martijn C.
Netherlands, Groningen
Rijksuniversiteit Groningen
Nikolić, Marko Z.
United Kingdom, London
University College London
Ordovás-Montañés, José M.
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
United States, Cambridge
Massachusetts Institute of Technology
United States, Cambridge
Harvard Stem Cell Institute
Oudit, Gavin Y.
Canada, Edmonton
University of Alberta
Pe'er, Dana
United States, New York
Memorial Sloan-kettering Cancer Center
Powell, Joseph E.
Australia, Sydney
Garvan Institute of Medical Research
Australia, Sydney
Unsw Sydney
Quake, Stephen R.
United States, Palo Alto
Stanford University
Rajagopal, Jay
United States, Cambridge
Harvard Stem Cell Institute
United States, Boston
Massachusetts General Hospital
Tata, Purushothama Rao
United States, Durham
Duke University School of Medicine
Rawlins L., Emma L.
United Kingdom, Cambridge
University of Cambridge
Regev, Aviv
United States, Cambridge
Massachusetts Institute of Technology
United States, Chevy Chase
Howard Hughes Medical Institute
Reyfman, Paul A.
United States, Chicago
Northwestern University Feinberg School of Medicine
Rozenblatt-Rosen, Orit
United States, Cambridge
Massachusetts Institute of Technology
Saeb-Parsy, Kourosh
United Kingdom, Cambridge
University of Cambridge
Samakovlis, Christos
Sweden, Stockholm
Stockholms Universitet
Germany, Giessen
Justus-liebig-universität Gießen
Schiller, Herbert B.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Seidman, Christine E.
United States, Boston
Harvard Medical School
United States, Chevy Chase
Howard Hughes Medical Institute
United States, Boston
Brigham and Women's Hospital
Seidman, Jonathan G.
United States, Boston
Harvard Medical School
Shalek, Alex K.
United States, Cambridge
Massachusetts Institute of Technology
Sun, Xin
United States, La Jolla
School of Biological Sciences
Teichmann, Sarah Amalia
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Cambridge
University of Cambridge
Theis, Fabian J.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Vallier, Ludovic
United Kingdom, Cambridge
Wellcome - Mrc Cambridge Stem Cell Institute
Xavier, Ramnik J.
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Massachusetts Institute of Technology
Zaragosi, Laure Emmanuelle
France, Valbonne
Institut de Pharmacologie Moléculaire et Cellulaire
Zhang, Kun
United States, La Jolla
University of California, San Diego
Rojas, Mauricio M.
United States, Pittsburgh
University of Pittsburgh
Statistics
Citations: 1,733
Authors: 58
Affiliations: 62
Identifiers
Doi:
10.1038/s41591-020-0868-6
ISSN:
10788956
Research Areas
Covid