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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Selection in the making: A worldwide survey of haplotypic diversity around a causative mutation in porcine IGF2
Genetics, Volume 178, No. 3, Year 2008
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Description
Domestic species allow us to study dramatic evolutionary changes at an accelerated rate due to the effectiveness of modern breeding techniques and the availability of breeds that have undergone distinct selection pressures. We present a worldwide survey of haplotype variability around a known causative mutation in porcine gene IGF2, which increases lean content. We genotyped 34 SNPs spanning 27 kb in 237 domestic pigs and 162 wild boars. Although the selective process had wiped out variability for at least 27 kb in the haplotypes carrying the mutation, there was no indication of an overall reduction in genetic variability of international vs. European local breeds; there was also no evidence of a reduction in variability caused by domestication. The haplotype structure and a plot of Tajima's D against the frequency of the causative mutation across breeds suggested a temporal pattern, where each breed corresponded to a different selective stage. This was observed comparing the haplotype neighbor-joining (NJ) trees of breeds that have undergone increasing selection pressures for leanness, e.g., European local breeds vs. Pietrain. These results anticipate that comparing current domestic breeds will decisively help to recover the genetic history of domestication and contemporary selective processes. Copyright © 2008 by the Genetics Society of America.
Authors & Co-Authors
Ojeda, Ana
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Huang, Lusheng
China, Nanchang
Jiangxi Agricultural University
Ren, J.
China, Nanchang
Jiangxi Agricultural University
Antonella, Angiolillo
Italy, Campobasso
Università Degli Studi Del Molise
Cho, In-cheol
South Korea, Jeonju
Rural Development Administration
Soto, H. W.
Costa Rica, San Jose
Universidad de Costa Rica
Lemuś-Flores, C.
Mexico, Tepic
Universidad Autónoma de Nayarit
Makuza, Stanley Marshall
Zimbabwe, Harare
University of Zimbabwe
Folch, Josep M.
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Pérez-Enciso, Miguel
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Statistics
Citations: 54
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1534/genetics.107.084269
ISSN:
00166731
e-ISSN:
00166731
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative