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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Artesunate/amodiaquine malaria treatment for Equatorial Guinea (Central Africa)
American Journal of Tropical Medicine and Hygiene, Volume 88, No. 6, Year 2013
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Description
The objectives of this study were: 1) to evaluate the safety and efficacy of combination artesunate (AS)/amodiaquine (AQ) therapy, and 2) to determine the difference between recrudescence and resistance. An in vivoefficacy study was conducted in Equatorial Guinea. A total of 122 children 6-59 months of age from two regionalhospitals were randomized and subjected to a 28-day clinical and parasitological follow-up. A blood sample on Whatmanpaper was taken on Days 0, 7, 14, 21, and 28 or on any day in cases of treatment failure, with the parasite DNA then beingextracted for molecular analysis purposes. A total of 4 children were excluded, and 9 cases were lost to follow-up. Therewere 17 cases of late parasitological failure, 3 cases of late clinical failure, and 89 cases of adequate clinical and parasitological response. The parasitological failure rate was 18.3% (20 of 109) and the success rate 81.70% (95% confidence interval [72.5-87.9%]). After molecular correction, real treatment efficacy stood at 97.3%. Our study showed the good efficacy of combination AS/AQ therapy. This finding enabled this treatment to be recommended to Equatorial Guinea's National Malaria Control Program to change the official treatment policy as of March 2008. Copyright © 2013 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Charle-Cuéllar, Pilar
Spain, Madrid
Instituto de Salud Carlos Iii
Berzosa, Pedro J.
Spain, Madrid
Centro Nacional de Medicina Tropical
de Lucio, Aída
Spain, Madrid
Centro Nacional de Medicina Tropical
Raso, José
Equatorial Guinea
Minsabs
Nseng, Gloria
Equatorial Guinea
Ministry of Health and Social Welfare
Benito, Agustìn
Spain, Madrid
Centro Nacional de Medicina Tropical
Statistics
Citations: 11
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.12-0290
ISSN:
00029637
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Equatorial Guinea
Guinea