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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Plasmodium falciparum produce lower infection intensities in local versus foreign anopheles gambiae populations
PLoS ONE, Volume 7, No. 1, Article e30849, Year 2012
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Description
Both Plasmodium falciparum and Anopheles gambiae show great diversity in Africa, in their own genetic makeup and population dynamics. The genetics of the individual mosquito and parasite are known to play a role in determining the outcome of infection in the vector, but whether differences in infection phenotype vary between populations remains to be investigated. Here we established two A. gambiae s.s. M molecular form colonies from Cameroon and Burkina Faso, representing a local and a foreign population for each of the geographical sites. Experimental infections of both colonies were conducted in Cameroon and Burkina Faso using local wild P. falciparum, giving a sympatric and allopatric vector-parasite combination in each site. Infection phenotype was determined in terms of oocyst prevalence and intensity for at least nine infections for each vector-parasite combination. Sympatric infections were found to produce 25% fewer oocysts per midgut than allopatric infections, while prevalence was not affected by local/foreign interactions. The reduction in oocyst numbers in sympatric couples may be the result of evolutionary processes where the mosquito populations have locally adapted to their parasite populations. Future research on vector-parasite interactions must take into account the geographic scale of adaptation revealed here by conducting experiments in natural sympatric populations to give epidemiologically meaningful results. © 2012 Harris et al.
Authors & Co-Authors
Harris, Caroline
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Tanzania, Ifakara
Ifakara Health Institute
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Morlais, Isabelle
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
France, Marseille
Ird Institut de Recherche Pour le Developpement
Churcher, Thomas S.
United Kingdom, London
Imperial College London
Awono-Ambéné, Parfait Herman
France, Marseille
Ird Institut de Recherche Pour le Developpement
Gouagna, Louis Clément
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Dabiré, Roch Kounbobr
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Fontenille, Didier
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Cohuet, Anna
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Statistics
Citations: 52
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0030849
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Burkina Faso
Cameroon