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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
CYP3A4 and VDR gene polymorphisms and the risk of prostate cancer in men with benign prostate hyperplasia
British Journal of Cancer, Volume 88, No. 6, Year 2003
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Description
Prostate cancer (PRCa) is one of the most common causes of cancer death in men and determinants of PRCa risk remain largely unidentified. Benign prostatic hyperplasia (BPH) is found in the majority of ageing men and has been associated with PRCa. Many candidate genes have been suggested to be involved in PRCa, such as those that are central to cellular growth and differentiation in the prostate gland. The vitamin D receptor (VDR) and CYP3A4 have been shown to be involved in the regulation of cell proliferation and differentiation in prostate cells. Genetic variations of these genes have been associated with PRCa in case - control studies and may be useful to detect BPH patients that have a higher risk of developing PRCa. The association between CYP3A4 and VDR Taql SNPs and the risk of developing PRCa have been investigated in this study by determining the variant genotype frequencies of both SNPs in 400 patients with BPH who have been followed clinically for a median of 11 years. The results of this study showed that the incidence rate of PRCa was higher in BPH patients having CYP3A4 variant genotype compared to those with wild type (relative risk (RR) = 2.7; 95% CI = 0.77-7.66). No association between variant genotype and risk of developing PRCa was observed with the VDR Taql variant genotype. In addition, the results of combined genotype analysis of these two SNPs showed a borderline significant association between CYP3A4 and VDR Taql combined variant genotypes and PRCa risk (RR = 3.43; 95% CI = 0.99-11.77). While independent confirmation is required in further studies, these results provide a potential tool to assist prediction strategies for this important disease. © 2003 Cancer Research UK.
Authors & Co-Authors
Tayeb, Mohammed Taher
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Saudi Arabia, Makkah
Umm Al-qura University
Clark, Caroline
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Haites, Nneva E.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Sharp, Linda
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Murray, Graeme I.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
McLeod, Howard Lewis
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
United States, St. Louis
Washington University in St. Louis
Statistics
Citations: 65
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1038/sj.bjc.6600825
Research Areas
Cancer
Genetics And Genomics
Study Design
Cohort Study
Participants Gender
Male