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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil
Viruses, Volume 14, No. 10, Article 2148, Year 2022
Notification
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Description
From a country with one of the highest SARS-CoV-2 morbidity and mortality rates, Brazil has implemented one of the most successful vaccination programs. Brazil’s first model city vaccination program was performed by the CoronaVac vaccine (Sinovac Biotech) in the town of Serrana, São Paulo State. To evaluate the vaccination effect on the SARS-CoV-2 molecular dynamics and clinical outcomes, we performed SARS-CoV-2 molecular surveillance on 4375 complete genomes obtained between June 2020 and April 2022 in this location. This study included the period between the initial SARS-CoV-2 introduction and during the vaccination process. We observed that the SARS-CoV-2 substitution dynamics in Serrana followed the viral molecular epidemiology in Brazil, including the initial identification of the ancestral lineages (B.1.1.28 and B.1.1.33) and epidemic waves of variants of concern (VOC) including the Gamma, Delta, and, more recently, Omicron. Most probably, as a result of the immunization campaign, the mortality during the Gamma and Delta VOC was significantly reduced compared to the rest of Brazil, which was also related to lower morbidity. Our phylogenetic analysis revealed the evolutionary history of the SARS-CoV-2 in this location and showed that multiple introduction events have occurred over time. The evaluation of the COVID-19 clinical outcome revealed that most cases were mild (88.9%, 98.1%, 99.1% to Gamma, Delta, and Omicron, respectively) regardless of the infecting VOC. In conclusion, we observed that vaccination was responsible for reducing the death toll rate and related COVID-19 morbidity, especially during the gamma and Delta VOC; however, it does not prevent the rapid substitution rate and morbidity of the Omicron VOC. © 2022 by the authors.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9609010/bin/viruses-14-02148-s001.zip
Authors & Co-Authors
Slavov, Svetoslav Nanev
Brazil, Sao Paulo
Instituto Butantan
Rodrigues, Evandra Strazza
Unknown Affiliation
Santos, Elaine Vieira
Brazil, Sao Paulo
Instituto Butantan
Borges, Josiane Serrano
Unknown Affiliation
Evaristo, Mariane
Unknown Affiliation
Fonseca, Vagner S.
Unknown Affiliation
Ribeiro, Gabriela Mauric Frossard
Brazil, Sao Paulo
Instituto Butantan
Marqueze, Elaine Cristina
Brazil, Sao Paulo
Instituto Butantan
Barros, Cláudia Renata Dos Santos Renata Dos Santos
Brazil, Sao Paulo
Instituto Butantan
Martins, Antonio Jorge
Brazil, Sao Paulo
Instituto Butantan
Coutinho, Luiz Lehmann
Brazil, Sao Paulo
Universidade de São Paulo
Calado, Rodrigo T.
Unknown Affiliation
Elias, Maria Carolina Quartim B.
Brazil, Sao Paulo
Instituto Butantan
Coccuzzo Sampaio, Sandra Coccuzzo
Brazil, Sao Paulo
Instituto Butantan
Giovanetti, Marta
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Italy, Rome
Università Campus Bio-medico Di Roma
Junior Alcantara, Luiz Carlos
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Covas, Dimas Tadeu
Brazil, Sao Paulo
Instituto Butantan
Haddad, Simone Kashima
Unknown Affiliation
Statistics
Citations: 5
Authors: 18
Affiliations: 4
Identifiers
Doi:
10.3390/v14102148
ISSN:
19994915
Research Areas
Covid
Maternal And Child Health