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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa
Neurology, Volume 68, No. 5, Year 2007
Notification
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Description
OBJECTIVE: To measure the frequency and associated risk factors of HIV dementia in an HIV clinic in Kampala, Uganda. METHODS: We systematically sampled 78 HIV-seropositive (HIV+) patients from an ambulatory HIV clinic. Participants underwent detailed sociodemographic, medical history, functional, neurologic, and neuropsychological evaluations. One hundred HIV-negative patients were recruited to provide normative data for the neuropsychological tests. A logistic regression model was constructed to determine risk factors associated with the diagnosis of HIV dementia. RESULTS: Thirty-one percent (24 of 78) of the HIV+ patients had HIV dementia. Advanced age and low CD4 T-lymphocyte count (CD4 count) were the only variables identified as significant risk factors in the logistic regression model. Each additional 10 years of age conferred a greater than twofold risk of HIV dementia (OR 2.06, 95% CI: 1.05 to 4.07; p < 0.05). Reduced levels of CD4 count (100 cells/μL decrement) was associated with a 60% increase in the odds of having HIV dementia (OR 1.6, 95% CI: 1.04 to 2.33; p < 0.05). CONCLUSION: HIV dementia is common in HIV-seropositive Ugandan individuals attending an AIDS clinic. It is more frequently associated with patients of advanced age and decreased CD4 count. ©2007AAN Enterprises, Inc.
Authors & Co-Authors
Wong, Matthew H.
Canada, Hamilton
Mcmaster University
United States, Charlottesville
University of Virginia Health System
Robertson, Kevin R.
United States, Chapel Hill
Unc School of Medicine
Nakasujja, Noeline
Uganda, Kampala
Makerere University
Skolasky, Richard Leroy
United States, Baltimore
Johns Hopkins University
Musisi, Seggane M.
Uganda, Kampala
Makerere University
Katabira, Elly Tebasoboke
Uganda, Kampala
Makerere University
McArthur, Justin Charles
United States, Baltimore
Johns Hopkins University
Ronald, Allan R.
Canada, Winnipeg
University of Manitoba
Sacktor, Ned Charlton
United States, Baltimore
Johns Hopkins University
Statistics
Citations: 56
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1212/01.wnl.0000252811.48891.6d
ISSN:
00283878
Research Areas
Health System And Policy
Infectious Diseases
Mental Health
Study Locations
Uganda