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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A role for interleukin-12/23 in the maturation of human natural killer and CD56
+
T cells in vivo
Blood, Volume 111, No. 10, Year 2008
Notification
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Description
Natural killer (NK) cells have been originally defined by their "naturally occurring" effector function. However, only a fraction of human NK cells is reactive toward a panel of prototypical tumor cell targets in vitro, both for the production of interferon-γ (IFN-γ) and fortheir cytotoxic response. In patients with IL12RB1 mutations that lead to a complete IL-12R(β1 deficiency, the size of this naturally reactive NK cell subset is diminished, in particular for the IFN-γ production. Similar data were obtained from a patient with a complete deficit in IL-12p40. In addition, the size of the subset of effector memory T cells expressing CD56 was severely decreased in IL-12Rβ1-and IL-12p40-deficient patients. Human NK cells thus require in vivo priming with IL-12/23 to acquire their full spectrum of functional reactivity, while T cells are dependent upon IL-12/23 signals for the differentiation and/or the maintenance of CD56+ effector memory T cells. The susceptibility of IL-12/23 axis-deficient patients to Mycobacterium and Salmonella infections in combination with the absence of mycobacteriosis or salmonellosis in the rare cases of human NK cell deficiencies point to a role for CD56+ T cells in the control of these infections in humans. © 2008 by The American Society of Hematology.
Authors & Co-Authors
Guia, Sophie
France, Marseille
Centre D’immunologie de Marseille-luminy
France, Marseille
Lnserm U631
France, Paris
Cnrs Centre National de la Recherche Scientifique
Cognet, Céline
France, Marseille
Centre D’immunologie de Marseille-luminy
France, Marseille
Lnserm U631
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Marseille
Hopital de la Conception
de Beaucoudrey, Ludovic
France, Paris
Inserm
France, Paris
Université Paris Cité
Tessmer, Marlowe S.
United States, Providence
Brown University
Jouanguy, Emmanuelle
France, Paris
Inserm
France, Paris
Université Paris Cité
Berger, Claire C.
France, Saint-etienne
Centre Hospitalier Universitaire de Saint Etienne
Filipe-Santos, Orchidée
France, Paris
Inserm
France, Paris
Université Paris Cité
Feinberg, Jacqueline
France, Paris
Inserm
France, Paris
Université Paris Cité
Camcioǧlu, Yildiz
Turkey, Istanbul
İstanbul Tıp Fakültesi
Levy, Jacob
Israel, Beer-sheva
Ben-gurion University of the Negev
Jumaah, Suliman Al
Saudi Arabia, Riyadh
King Abdulaziz Hospital and Research Center
Al-Hajjar, Sami Hussain
Saudi Arabia, Riyadh
King Abdulaziz Hospital and Research Center
Stéphan, Jean Louis
France, Saint-etienne
Centre Hospitalier Universitaire de Saint Etienne
Fieschi, Claire
France, Paris
Hôpital Saint-louis
Abel, Laurent
France, Paris
Inserm
France, Paris
Université Paris Cité
Brossay, Laurent
United States, Providence
Brown University
Casanova, Jean Laurent
France, Paris
Inserm
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
Vivier, Éric
France, Marseille
Centre D’immunologie de Marseille-luminy
France, Marseille
Hopital de la Conception
Statistics
Citations: 65
Authors: 18
Affiliations: 13
Identifiers
Doi:
10.1182/blood-2007-11-122259
ISSN:
00064971
Research Areas
Cancer
Health System And Policy
Infectious Diseases