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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Serum lipoprotein profile in Algerian patients with celiac disease
Clinica Chimica Acta, Volume 235, No. 2, Year 1995
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Description
Celiac disease is characterized by a gluten-induced villous atrophy of the upper small intestine which has an active role in the lipoprotein metabolism. In the present study the lipoprotein profiles of different patients were analyzed to determine the effect of impaired enterocyte function in celiac disease. We compared serum lipid parameters in controls and in celiac disease patients. The major differences between celiac disease patients and the control group were a diminution of cholesterol and phospholipids in HDL and LDL in the former. These differences persisted after treatment; in addition, a lower level of cholesterol in VLDL was observed. Plasma LpAI and apo A-I levels were significantly lower (-17 and -15%) in celiac disease patients than in controls. Both levels remained low after gluten-free diet. In Algerian patients, treatment with gluten-free diet did not give any return towards normal lipids concentrations. © 1995.
Authors & Co-Authors
Mediene-Benchekor, S.
Algeria, Oran
Université Oran 1
Hakem, Saliha
Algeria, Oran
Hôpital D'oran
Bard, Jean Marie
France, Lille
Institut Pasteur de Lille
Medjaoui, I.
Algeria, Oran
Secteur Sanitaire Iv
Benhamamouch, Soraya
Algeria, Oran
Université Oran 1
Lebel, P.
France, Lille
Institut Pasteur de Lille
Fruchart, Jean Charles
France, Lille
Institut Pasteur de Lille
Clavey, Vèronique
France, Lille
Institut Pasteur de Lille
Statistics
Citations: 14
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/0009-8981(95)06028-1
ISSN:
00098981
Study Design
Randomised Control Trial