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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Different epidemic potentials of the HIV-1B and C subtypes
Journal of Molecular Evolution, Volume 60, No. 5, Year 2005
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Description
HIV, the cause of AIDS in humans, is characterized by great genetic heterogeneity. In particular, HIV-1 group M subtypes are responsible for most of the infections worldwide. We investigate the demographic history of HIV-1B and HIV-1C subtypes in South Africa and Brazil using both a parametric and a nonparametric approach based on coalescent theory. Our results show that although both subtypes are spreading exponentially in Brazil, the HIV-1C growth rate is about twice that of Brazilian HIV-1B or South African HIV-1C, providing evidence, for the first time, of a different epidemic potential between two HIV-1 subtypes. The present study not only may have important consequences for devising future vaccination and therapeutic strategies, but also offers additional evidence that skyline plots are indeed a simple and powerful tool for monitoring and predicting the behavior of viral epidemics. © Springer Science+Business Media, Inc. 2005.
Authors & Co-Authors
Salemi, Marco
United States, Irvine
University of California, Irvine
United States, Gainesville
University of Florida
De Oliveira, Tulio
South Africa, Durban
The Nelson R. Mandela Medical School
Soares, Marcelo Alves
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Pybus, Oliver George
United Kingdom, Oxford
University of Oxford
Dumans, Ana Teresa Nogueira
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Vandamme, Anne Mieke
Belgium, Leuven
Rega Institute for Medical Research
Tanuri, Amílcar
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Cassol, Sharon A.
South Africa, Durban
The Nelson R. Mandela Medical School
Fitch, Walter M.
United States, Irvine
University of California, Irvine
Statistics
Citations: 60
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1007/s00239-004-0206-5
ISSN:
00222844
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
South Africa