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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mitral Valve Infective Endocarditis after Trans-Catheter Aortic Valve Implantation
American Journal of Cardiology, Volume 172, Year 2022
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Description
Scarce data exist on mitral valve (MV) infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI). This multicenter study included a total of 579 patients with a diagnosis of definite IE after TAVI from the IE after TAVI International Registry and aimed to evaluate the incidence, characteristics, management, and outcomes of MV-IE after TAVI. A total of 86 patients (14.9%) had MV-IE. These patients were compared with 284 patients (49.1%) with involvement of the transcatheter heart valve (THV) only. Two factors were found to be associated with MV-IE: the use of self-expanding valves (adjusted odds ratio 2.49, 95% confidence interval [CI] 1.23 to 5.07, p = 0.012), and the presence of an aortic regurgitation ≥2 at discharge (adjusted odds ratio 3.33; 95% CI 1.43 to 7.73, p <0.01). There were no differences in IE timing and causative microorganisms between groups, but surgical management was significantly lower in patients with MV-IE (6.0%, vs 21.6% in patients with THV-IE, p = 0.001). All-cause mortality rates at 2-year follow-up were high and similar between patients with MV-IE (51.4%, 95% CI 39.8 to 64.1) and patients with THV-IE (51.5%, 95% CI 45.4 to 58.0) (log-rank p = 0.295). The factors independently associated with increased mortality risk in patients with MV-IE were the occurrence of heart failure (adjusted p <0.001) and septic shock (adjusted p <0.01) during the index hospitalization. One of 6 IE episodes after TAVI is localized on the MV. The implantation of a self-expanding THV and the presence of an aortic regurgitation ≥2 at discharge were associated with MV-IE. Patients with MV-IE were rarely operated on and had a poor prognosis at 2-year follow-up. © 2022 Elsevier Inc.
Authors & Co-Authors
Abdel-Wahab, Mohamed Kader
Germany, Leipzig
Herzzentrum Leipzig
Germany, Bad Segeberg
Segeberger Kliniken
Durand, Éric
France, Caen
Normandie Université
Ihlemann, Nikolaj
Denmark, Copenhagen
Rigshospitalet
Pellegrini, Costanza
Germany, Munich
Technische Universität München
Giannini, F.
Italy, Milan
Irccs Ospedale San Raffaele
Huczek, Zenon
Poland, Warsaw
Medical University of Warsaw
Landt, Martin
Germany, Bad Segeberg
Segeberger Kliniken
Sinning, Jan Malte
Unknown Affiliation
Cheema, Asim N.
Canada, Toronto
Saint Michael's Hospital University of Toronto
Canada, Newmarket
Southlake Regional Health Centre
Nombela-Franco, Luís
Spain, Madrid
Hospital Clínico San Carlos
Campelo-Parada, Francisco
France, Toulouse
Hôpital Rangueil
Testa, Luca
Italy, San Donato Milanese
Gruppo Ospedaliero San Donato
Kim, Won-keun
Germany, Bad Nauheim
Kerckhoff Heart and Thorax Center
Tchétché, Didier
France, Toulouse
Clinique Pasteur
Bartorelli, Antonio L.
Italy, Milan
Università Degli Studi Di Milano
Kapadia, Samir R.
United States, Cleveland
Cleveland Clinic Foundation
Stortecky, Stefan
Switzerland, Bern
University of Bern
Amat, Ignacio J.
Spain, Madrid
Centro de Investigación en Red en Enfermedades Cardiovasculares
Wijeysundera, Harindra Channa
Canada, Toronto
Sunnybrook Health Sciences Centre
Livi, Ugolino
Italy, Udine
Policlinico Universitario, Udine
Lerakis, Stamatios
United States, Atlanta
Emory University School of Medicine
United States, New York
The Mount Sinai Hospital
Kappert, Utz W.
Germany, Dresden
Herzzentrum Dresden Universitätsklinik
Barbanti, Marco
Italy, Catania
Azienda Ospedaliero Universitaria Policlinico G.rodolico - San Marco
Fiorina, Claudia
Italy, Brescia
Spedali Civili Di Brescia
Miceli, Antonio
Italy, Milan
Istituto Clinico Sant’ambrogio
Ireland, Galway
University Hospital Galway
Kodali, Susheel K.
United States, New York
Columbia University Irving Medical Center
Ribeiro, Henrique B.
Brazil, Sao Paulo
Universidade de São Paulo
Brazil, Sao Paulo
Hospital Samaritano
Mangione, José Armando
Brazil, Paraiso
Beneficenca Portuguesa Hospital Sao Paulo
de Brito, Fábio Sândoli
Brazil, Sao Paulo
Universidade de São Paulo
Abizaid, Alexandre A.C.
Brazil, Sao Paulo
Universidade de São Paulo
Alfonso, Fernando
Spain, Madrid
Hospital Universitario de la Princesa
Eltchaninoff, Helénè
France, Caen
Normandie Université
Søndergaard, Lars
Denmark, Copenhagen
Rigshospitalet
Latib, Azeem M.
Italy, Milan
Irccs Ospedale San Raffaele
United States, New York
Montefiore Medical Center
Servoz, Clément
France, Toulouse
Hôpital Rangueil
Webb, John G.
Canada, Vancouver
St. Paul's Hospital, Vancouver
Sponga, Sandro
Italy, Udine
Policlinico Universitario, Udine
Makkar, Rajendra R.
United States, Los Angeles
Cedars-sinai Medical Center
Kini, Annapoorna S.
United States, New York
The Mount Sinai Hospital
Boukhris, Marouane
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Holzhey, David Michael
Germany, Leipzig
Herzzentrum Leipzig
Rodés-Cabau, Josep
Canada, Quebec
Université Laval
Statistics
Citations: 3
Authors: 42
Affiliations: 55
Identifiers
Doi:
10.1016/j.amjcard.2022.02.034
ISSN:
00029149
Research Areas
Health System And Policy
Study Design
Cohort Study
Case-Control Study