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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Identification and molecular characterization of subsubtype A4 in Central Africa
AIDS Research and Human Retroviruses, Volume 22, No. 2, Year 2006
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Description
Phylogenetic analysis on partial env sequences of HIV-1-positive samples obtained from sentinel population groups in HIV serosurveillance studies in 1997 and 2002 in the Democratic Republic of Congo (DRC) revealed a high genetic diversity in the number of cocirculating subtypes/CRFs as well as intrasubtype diversity. A cluster of three strains that formed a distinct and well-separated group within the subtype A radiation was observed. To determine a more precise structure of these viruses, the full-length genomes were sequenced. Phylogenetic tree and bootscan analysis showed that all three newly characterized viruses formed a new non-recombinant lineage that was more closely related to subtype A. The SUDI (Subtype Distance) program showed that the distances of the newly derived HIV-1 sequences to subtype A references fell in the range of distances previously characterized for subsubtypes. According to current nomendature rules, we have thus designated this new lineage as subsubtype A4. Analysis of viral sequences from other African countries suggests that the A4 strains seem restricted to DRC where they already circulated at the onset of the HIV/AIDS epidemic. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Vidal, Nicole
France, Montpellier
Ird Centre de Montpellier
Mulanga, Claire
France, Montpellier
Ird Centre de Montpellier
Bazepeo, Samuel Edidi
Democratic Republic Congo
Laboratoire du Pnls
Lepira, François Bompeka
Democratic Republic Congo
Pnls
Delaporte, Éric
France, Montpellier
Ird Centre de Montpellier
Peeters, Martine F.
France, Montpellier
Ird Centre de Montpellier
France, Marseille
Ird Institut de Recherche Pour le Developpement
Statistics
Citations: 44
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1089/aid.2006.22.182
ISSN:
08892229
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Congo