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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Métastases extranévraxiques du médulloblastome : aspects cliniques et facteurs de risque
Cancer/Radiotherapie, Volume 10, No. 3, Year 2006
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Description
Purpose: Extra-central nervous system (extra-CNS) metastases are relatively unknown failure patterns in medulloblastoma. The aim of this study was to analyse epidemiological, clinical and aetiopathological aspects of these extra-CNS localisations. Patients and methods: Extra-CNS metastases were retrospectively identified in patients treated in the department of radiation therapy at Salah-Azaïz institute (ISA) for medulloblastoma. These metastases were diagnosed as extra-CNS for all secondary localisations not related to other tumour aetiology. Aetiopathological aspects are discussed with a literature review. Results: Among 103 patients treated and followed-up in the department of radiation therapy of ISA from 1970 to 1992, 8 developed extra-CNS metastases (7.7%). Age at diagnosis of primitive tumour varied from 3 to 23 years. Sex ratio was 1. Primitive tumour treatment was: complete surgical resection in 4 patients with preoperative cerebrospinal fluid shunting in two, cerebrospinal axis irradiation in 7 patients and a cerebral-limited irradiation in 1. Two patients received chemotherapy for their initial treatment (systemic in one case and intrathecal in the other). The mean free-interval from diagnosis of primitive tumour to extra-CNS metastases was 23 months, varying from 8 to 53 months. These metastases were located in the liver (1 case), cervical lymph nodes (2 cases), bone marrow (1 case) and bone (2 cases). Two patients had multiple metastases: bone and bone marrow (in one), lung, pleura, cervical lymph node and bone localisations (in one). Treatment of these metastases was: chemotherapy in 5 cases, chemotherapy and radiation in one, radiation therapy in one and 2 patients were given only supportive care treatment. All patients died or are in progressive disease in less than one year from the diagnosis of extra-CNS metastases. Conclusion: Extra-CNS metastases are not rare and have a poor prognosis. The most commonly involved sites are bone, cervical lymph nodes and bone marrow. A complete work-up at initial diagnosis is recommended to screen early metastases. Literature review showed that histopathologic grading might help to identify groups at risk. © 2006 Elsevier SAS. All rights reserved.
Authors & Co-Authors
Kochbati, Lotfi
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Bouaouina, Noureddine
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Hentati, Dalenda
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Nasr, Chiraz
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Besbes, Mounir
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Benna, Farouk
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Boussen, Hamouda
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Maâlej, Mongi
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Statistics
Citations: 19
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1016/j.canrad.2006.02.004
ISSN:
12783218
Research Areas
Cancer
Health System And Policy
Study Approach
Systematic review