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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Peste des Petits Ruminants (PPR) virus serological surveillance in goats in Lao PDR: Issues for disease eradication in a low-resource disease-free setting
Transboundary and Emerging Diseases, Volume 66, No. 2, Year 2019
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Description
Peste des Petits ruminants (PPR) is an economically important transboundary viral disease of goats. This study aimed to determine a baseline of serological evidence for Peste des petits ruminants virus (PPRV) in Lao goats. A total of 1,072 serum samples were collected by convenience sampling across five provinces in Laos and tested for antibody response to PPRV using a commercially available competitive ELISA. Positive antibody responses were found in 2.2% (95% CI 1.4, 3.2) of the samples. True prevalence calculations indicated a total overall sample prevalence of 1.7% (95% CI 0.9, 2.8). The highest provincial seroprevalences were Xiangkhouang (3.5%, 95% CI 1.6, 6.9) and Xayaboury (2.9% (95% CI 1.3, 5.7). There was no association between antibody response and each of the following factors: location, breed, gender or age. Considering the apparent absence of disease manifestation of PPR in Laos, likely explanations for the antibody positivity could include cross reaction to other Morbilliviruses such as Measles or Canine Distemper, importation of pre-vaccinated goats, need for test cut-off re-evaluation to be region specific, or a subclinical and a less virulent circulating virus. This study highlights that the sampled Lao goat population is highly likely to be naïve to PPRV and therefore at risk of an outbreak, possibly by transboundary incursion of livestock from PPR endemic China. Further work is required in the testing of small ruminants in Laos that may eventually provide evidence for a status of freedom from disease, particularly in support of programs aimed at global PPR eradication. © 2018 The Authors. Transboundary and Emerging Diseases published by Blackwell Verlag GmbH
Authors & Co-Authors
Douangngeun, Bounlom
Laos, Vientiane
Ministry of Agriculture and Forestry
Theppangna, Watthana
Laos, Vientiane
Ministry of Agriculture and Forestry
Mukaka, Mavuto F.J.
Thailand, Bangkok
Mahidol Oxford Tropical Medicine Research Unit
United Kingdom, Oxford
University of Oxford
Windsor, PA Andrew
Australia, Sydney
The University of Sydney
Blacksell, Stuart D.
Thailand, Bangkok
Mahidol Oxford Tropical Medicine Research Unit
United Kingdom, Oxford
University of Oxford
Thailand
Mahosot Hospital, Lao
Statistics
Citations: 9
Authors: 5
Affiliations: 6
Identifiers
Doi:
10.1111/tbed.13109
ISSN:
18651674
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study