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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical outcome after CO2 laser laparoscopic radical excision of endometriosis with colorectal wall invasion combined with laparoscopic segmental bowel resection and reanastomosis
Human Reproduction, Volume 26, No. 9, Year 2011
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Description
Background Laparoscopic segmental bowel resection and reanastomosis for endometriosis with colorectal wall invasion can be associated with high complication rates. This study was performed to test the hypothesis that this high complication rate can be prevented and combined with a good clinical outcome, following a multidisciplinary surgical approach. Methods a retrospective cohort study of all patients with deep endometriosis and colorectal invasion treated by CO2 laser laparoscopic radical excision between September 2004 and September 2006 (n = 45) to document the clinical outcome: complications, recurrence and fertility (life table analysis), pain, quality of life (QOL) and sexual function. Results No immediate major post-operative complications requiring surgical reintervention were recorded. Gynaecological pain (P< 0.0001), sexual function (P< 0.03) and QOL (P< 0.0001), improved significantly after a median follow-up period of 27 (range: 1640) months. Although five patients (11) had a surgical reintervention, histologically proven recurrent endometriosis was observed in only two (4), with a cumulative endometriosis recurrence rate of 2.2 and 4.4 after 1 and 3 years, respectively. Thirteen of 28 patients who wanted to become pregnant conceived after surgery. One patient delivered twice. These 14 pregnancies were achieved spontaneously (n 9) or after IVF (n 5). The cumulative pregnancy rate was 47 after 3 years. Conclusion Pain, sexual function and QOL improved significantly and were associated with a good fertility rate and a low complication and recurrence rate after a CO2 laser laparoscopic radical excision of endometriosis with colorectal wall invasion combined with laparoscopic segmental bowel resection and reanastomosis. © 2011 The Author.
Authors & Co-Authors
Meuleman, Christel L.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Tomassetti, Carla
Belgium, Leuven
Ku Leuven– University Hospital Leuven
D'Hoore, André J.L.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Fieuws, Steffen
Belgium, Leuven
Ku Leuven
Penninckx, Freddy M.A.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
VERGOTE, Ignace B.P.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
D'Hooghe, Thomas Maria
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Statistics
Citations: 53
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1093/humrep/der231
ISSN:
02681161
Research Areas
Disability
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Quantitative