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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Induction of labor with mifepristone (RU 486) in intrauterine fetal death
American Journal of Obstetrics and Gynecology, Volume 163, No. 2, Year 1990
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Description
In a double-blind controlled multicentric study involving 94 patients with an intrauterine fetal death, we investigated the efficacy and tolerance of mifepristone (RU 486), a steroid compound that antagonizes progesterone action at the receptor level. Success of treatment was defined as the occurrence of fetal expulsion within 72 hours after the first drug intake. Mifepristone treatment (600 mg per day for 2 days) was considered to be effective in 29 of 46 patients (63%). There were only eight successes in 48 patients (17.4%) in the placebo group (p = 0.001, χ2 test). Tolerance was good in the mifepristone group. In the placebo group, disseminated intravascular coagulation occurred in one woman for whom the investigator waited several weeks for spontaneous expulsion. This large double-blind controlled study provides evidence that mifepristone is of interest in the management of intrauterine fetal death. It could provide a pharmacologic alternative to the use of prostaglandins in this indication. © 1990.
Authors & Co-Authors
Cabrol, Dominique
France, Paris
Hopital Cochin Ap-hp
Dubois, C.
France, Gentilly
Sanofi S.a.
Cronjé, H. S.
France, Bordeaux
University Orange Free State
Gonnet, J. M.
France, Bordeaux
Groupe Hospitalier Pellegrin
Guillot, M.
France, Marseille
Clinique Saint-martin
Maria, B.
France, Pontoise
Centre Hospitalier Intercommunal
Moodley, Jagdisea M.
South Africa, Durban
University of Kwazulu-natal
Oury, Jean François
France, Cergy-pontoise
Centre Hospitalier René Dubos
Thoulon, J. M.
France, Lyon
Hopital de L'hotel-dieu Chu Lyon
Treisser, Alain
South Africa, Bloemfontein
Centre Hospitalier Régional
Ulmann, D.
South Africa, Durban
Hôpital Louis Pasteur Durban
Correl, S.
France, Gentilly
Sanofi S.a.
Ulmann, A.
France, Gentilly
Sanofi S.a.
Statistics
Citations: 67
Authors: 13
Affiliations: 11
Identifiers
Doi:
10.1016/0002-9378(90)91193-G
ISSN:
00029378
Research Areas
Disability
Participants Gender
Female