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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Tyro3 family-mediated cell entry of Ebola and Marburg viruses
Journal of Virology, Volume 80, No. 20, Year 2006
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Description
Filoviruses, represented by the genera Ebolavirus and Marburgvirus, cause a lethal hemorrhagic fever in humans and in nonhuman primates. Although filovirus can replicate in various tissues or cell types in these animals, the molecular mechanisms of its broad tropism remain poorly understood. Here we show the involvement of members of the Tyro3 receptor tyrosine kinase family-Axl, Dtk, and Mer-in cell entry of filoviruses. Ectopic expression of these family members in lymphoid cells, which otherwise are highly resistant to filovirus infection, enhanced infection by pseudotype viruses carrying filovirus glycoproteins on their envelopes. This enhancement was reduced by antibodies to Tyro3 family members, Gas6 ligand, or soluble ectodomains of the members. Live Ebola viruses infected both Axl- and Dtk-expressing cells more efficiently than control cells. Antibody to Axl inhibited infection of pseudotype viruses in a number of Axl-positive cell lines. These results implicate each Tyro3 family member as a cell entry factor in filovirus infection. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Shimojima, Masayuki
Japan, Tokyo
The University of Tokyo
Japan, Kawaguchi
Japan Science and Technology Agency
Takada, Ayato
Japan, Sapporo
Hokkaido University
Ebihara, Hideki
Japan, Tokyo
The University of Tokyo
Japan, Kawaguchi
Japan Science and Technology Agency
Canada, Ottawa
Public Health Agency of Canada
Neumann, Gabriele G.
United States, Madison
University of Wisconsin-madison
Jones, Steven M.
Canada, Ottawa
Public Health Agency of Canada
Canada, Winnipeg
University of Manitoba
Feldmann, Heinz
Canada, Ottawa
Public Health Agency of Canada
Canada, Winnipeg
University of Manitoba
Kawaoka, Yoshihiro K.
Japan, Tokyo
The University of Tokyo
Japan, Kawaguchi
Japan Science and Technology Agency
United States, Madison
University of Wisconsin-madison
Statistics
Citations: 272
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1128/JVI.01157-06
ISSN:
0022538X
Research Areas
Infectious Diseases