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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association of risk factors with acute myocardial infarction in Middle Eastern countries: The INTERHEART Middle East study
European Journal of Preventive Cardiology, Volume 21, No. 4, Year 2014
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Description
Background and objectives: Mortality from cardiovascular disease in the Middle East (ME) is projected to increase substantially by 2020. There are no large studies on the impact of risk factors for acute myocardial infarction (AMI) in the region. This is a report on the association of nine risk factors with AMI in the ME. Methods and results: As part of the INTERHEART (IH) study, we enrolled 1364 cases of first AMI and 1525 matching controls from eight ME countries. The age at first AMI was 51.2± 10.3 years, which is the youngest, and with the largest proportion of patients <40 years in the entire IH population. The overall population attributable risk (PAR) of the nine risk factors to AMI was higher in the ME (97.5%) than worldwide (90.4%). Elevated apolipoprotein (Apo)B/ApoA1 had the strongest association with AMI, with odds ratio (OR) of 3.43 and PAR of 57.1%, followed by smoking (OR 3.63 and PAR 45.6%). ApoB/ApoA1 had greater association than the conventional low-density lipoprotein (LDL)/high-density lipoprotein (HDL) cholesterol ratio. Both diabetes (OR 3.42, PAR 16.4%) and hypertension (OR 1.89, PAR 10.7%) had greater association with AMI in women than men. Abdominal obesity (OR 2.12, PAR 26.1%) and depression (OR 1.97, PAR 45.3%), but not conventional BMI, were significantly associated with AMI (p <0.0001). Conclusion: This is the largest prospective population study of risk factors associated with AMI in the ME. AMI occurs at younger age in the ME than all other regions. The PAR for the nine risk factors was higher in the ME (97.5%) than the rest of the world. These findings should guide serious prevention strategies. © The European Society of Cardiology 2012.
Authors & Co-Authors
Gehani, Abdurrazzak A.
Qatar, Doha
Weill Cornell Medicine-qatar
Al-Hinai, Ali Talib
Oman, Muscat
Sultan Qaboos University
Zubaid, Mohammad
Kuwait, Kuwait City
Kuwait University
Al-Mahmeed, Wael Abdulrahman R.
United Arab Emirates, Abu Dhabi
Sheikh Khalifa Medical City
Hasani, Mohammad
Iran
Islamic Asaz University
Yusufali, Afzal Hussein
United Arab Emirates, Dubai
Dubai Hospital
Hassan, Mohammed Osman
Qatar, Doha
Weill Cornell Medicine-qatar
Lewis, Basil S.
Israel, Haifa
Carmel Medical Center
Islam, Shofiqul
Canada, Hamilton
Hamilton Health Sciences
Rangarajan, Sumathy
Canada, Hamilton
Hamilton Health Sciences
Yusuf, Salim N.
Canada, Hamilton
Hamilton Health Sciences
Statistics
Citations: 92
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1177/2047487312465525
ISSN:
20474873
Research Areas
Mental Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Participants Gender
Male
Female