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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Tuberculosis genes expressed during persistence and reactivation in the resistant rabbit model
Tuberculosis, Volume 89, No. 1, Year 2009
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Description
As previously published, after aerosol infection with Mycobacterium tuberculosis H37Rv, New Zealand white rabbits established infection with active bacillary replication, but later contained disease to a paucibacillary state through an effective adaptive response consistent with latency. Despite the heterogeneity among outbred rabbits, the resistant response was uniform. Immunosuppression resulted in reactivation with increased lung bacillary burden. Using this rabbit model, we isolated bacillary RNA from infected rabbit lungs and assessed transcriptional profiles of bacillary genes using RT-PCR to examine genes differentially regulated during active replication, persistence, steroid-induced reactivation, and post-steroid immune reconstitution. Genes involved in hypoxia response (fdxA), resuscitation promoting factors (rpfB), and DNA repair pathways (Rv2191) may be important in bacillary persistence. Further investigation into these gene pathways is warranted. © 2008 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Kesavan, Anup K.
United States, Baltimore
Johns Hopkins University
Brooks, Megan
United States, Baltimore
Johns Hopkins University
Tufariello, Jo Ann M.
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Chan, John
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Manabe, Yukari C.
United States, Baltimore
Johns Hopkins University
Uganda, Kampala
Infectious Diseases Institute
Statistics
Citations: 49
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.tube.2008.08.004
ISSN:
14729792
Research Areas
Cancer
Genetics And Genomics