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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The schistosome egg granuloma: Immunopathology in the cause of host protection or parasite survival?
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 80, No. 4, Year 1986
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Description
The granulomatous inflammatory response induced by schistosome eggs entrapped in the microvasculature of host tissues is considered responsible for much of the symptomatology of schistosomiasis. However, the evolutionary role of the egg granuloma in the host-parasite relationship is not yet well defined. Some evidence indicates that the lesion may protect the host, either by shielding tissues against toxic egg products, or by interfering with the migration patterns of secondary infections, and thereby non-specifically contributing to the host’s acquired “immunity”. We here review earlier work concerned with the role of the egg granuloma in the host-parasite relationship in schistosomiasis, and we present new experimental evidence to suggest that the function of this cell-mediated immune response might, in addition to its putative host protective function, facilitate the extravasation of parasite eggs in the mesenteries, and thereby contribute directly to the continuation of the schistosome life-cycle. © 1986, Oxford University Press.
Authors & Co-Authors
Doenhoff, Michael J.
Unknown Affiliation
Hassounah, Osama A.
Unknown Affiliation
Murare, H. M.
Unknown Affiliation
Bain, J.
Unknown Affiliation
Lucas, Sebastian B.
Unknown Affiliation
Statistics
Citations: 99
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/0035-9203(86)90126-4
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Environmental
Infectious Diseases