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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
BAFF enhances chemotaxis of primary human B cells: A particular synergy between BAFF and CXCL13 on memory B cells
Blood, Volume 111, No. 5, Year 2008
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Description
B-cell-activating factor of the TNF family, (BAFF), and a proliferation-inducing li-gand (APRIL) regulate B-lymphocyte survival and activation. We report that BAFF, but not APRIL, increased the chemotactic response of primary human B cells to CCL21, CXCL12, and CXCL13. The BAFF-induced increase in B-cell chemotaxis was totally abolished by blockade of BAFF-R and was strongly dependent on the activation of PI3K/AKT, NF-κB, and p38MAPK pathways. BAFF had similar effects on the chemotaxis of naive and memory B cells in response to CCL21 but increased more strongly that of memory B cells to CXCL13 than that of naive B cells. Our findings indicate a previously unreported role for the BAFF/BAFF-R pair in mature B-cell chemotaxis. The synergy between CXCL13 and BAFF produced by stromal cells and follicular dendritic cells may have important implications for El-cell homeostasis, the development of normal B-cell areas, and for the formation of germinal center-like follicles that may be observed in various autoimmune diseases. © 2008 by The American Society of Hematology.
Authors & Co-Authors
Badr, Gamal
France, Gif-sur-yvette
Université Paris-saclay
Lefèvre, Eric A.
United Kingdom, Surrey
The Pirbright Institute
Dessirier, Valérie
France, Paris
Inserm
Tsapis, Andréas
France, Paris
Inserm
Richard, Yolande
France, Gif-sur-yvette
Université Paris-saclay
France, Gif-sur-yvette
Institut Des Maladies Emergentes et Des Thérapies Innovantes
Statistics
Citations: 113
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1182/blood-2007-03-081232
ISSN:
00064971