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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparative investigation of bone mineral density using CT and DEXA in a canine femoral model
Journal of Orthopaedic Research, Volume 35, No. 12, Year 2017
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Description
Bone density measurements using computed tomography (CT) instead of dual-energy X-ray absorptiometry (DEXA) are currently of great interest in human and veterinary medical research as it would be beneficial to use CT scans obtained for other indications also for determining bone density. For Hounsfield units (HU) measured with CT in specific regions of interests (ROIs) in one or several slice/s a correlation with bone mineral density (BMD) measured by DEXA in humans and dogs of between 0.44 and 0.77 is reported in the literature. In the present study, instead certain volumes of interest (VOIs) obtained by CT scan and the corresponding HU to the respective VOIs were compared with the bone mineral density of the corresponding areas measured by DEXA. The aim of the study was to investigate whether this procedure gives more accurate information about bone density of the bones as three-dimensional objects of the respective patient. Correlation between measured HU in the respective VOI and BMD measured with DEXA in the corresponding ROI showed a very good correlation of 0.93. Linear regression with R2 = 0.85 (p = 0.0262) was calculated. Except for VOI5, similar distribution of values and significant differences (p < 0.0001–0.0087) between ROIs/VOIs were detected. Determining HU for assessing bone mineral density in a certain volume provides more accurate results than those previously reported from two-dimensional (2D) CT measurements. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2667–2672, 2017.
Authors & Co-Authors
Lucas, Karin
Germany, Hannover
Tierärztliche Hochschule Hannover
Behrens, B. A.
Germany, Hannover
Gottfried Wilhelm Leibniz Universität Hannover
Nolte, Ingo J.A.
Germany, Hannover
Tierärztliche Hochschule Hannover
Galindo-Zamora, Vladimir
Colombia, Bogota
Universidad Nacional de Colombia
Betancur, Stefanie
Germany, Hannover
Gottfried Wilhelm Leibniz Universität Hannover
Almohallami, Amer
Germany, Hannover
Gottfried Wilhelm Leibniz Universität Hannover
Bouguecha, Anas
Germany, Hannover
Gottfried Wilhelm Leibniz Universität Hannover
Mostafa, Ayman A.
Egypt, Giza
Faculty of Veterinary Medicine
Lerch, Matthias
Germany, Hannover
Hannover Medical School
Stukenborg-Colsman, Christina
Germany, Hannover
Hannover Medical School
Wefstaedt, Patrick
Germany, Hannover
Tierärztliche Hochschule Hannover
Statistics
Citations: 11
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1002/jor.23574
ISSN:
07360266
e-ISSN:
1554527X
Research Areas
Health System And Policy