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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis
Arteriosclerosis, Thrombosis, and Vascular Biology, Volume 30, No. 12, Year 2010
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Description
Objective- To investigate whether chromosome 10q11.21 influences common carotid intima-media thickness (IMT) and atherosclerosis and whether it is associated with stromal cell-derived factor-1α (SDF-1α) plasma levels. Methods and Results- Variation on chromosome 10q11.21 has been consistently associated with coronary artery disease. The genetic variant lies upstream of the gene encoding SDF-1α. We genotyped 3 population cohorts (Bruneck [age range, 45 to 94 years; 50.0% men; n=738], Health2000 [age range, 46 to 76 years; 55.4% men; n=1237], and essential hypertension in families collected in the region of Oxford [HTO] [age range, 19 to 88 years; 47.9% men; n=770]) for single-nucleotide polymorphism rs501120 at the 10q11.21 locus and conducted a meta-analysis in these cohorts to ascertain a relationship between the polymorphism and carotid IMT. The analysis showed that individuals with the T/T genotype had a significantly higher carotid IMT than individuals with the C/T or C/C genotype (pooled weighted mean difference, 23 μm [95% CI, 9 to 37 μm], P=0.0014 under a fixed-effects model; and 23 μm [95% CI, 6 to 41 μm], P=0.009 under a random-effects model). In the Bruneck cohort, in which data for carotid atherosclerosis and plasma SDF-1α levels were available, we observed an association of the T/T genotype with a higher burden of atherosclerosis and increased susceptibility to the development of atherosclerosis during a 5-year follow-up (multivariable odds ratio, 1.73 [95% CI, 1.18 to 2.52]; P=0.005 for the recessive model) and an association between the T/T genotype and lower SDF-1α levels (2.62 ng/mL for T/T versus 2.74 ng/mL for C/C or C/T; P=0.023). Conclusion- The coronary heart disease-related variant at the 10q11.21 locus is associated with carotid IMT and atherosclerosis. © 2010 American Heart Association. All rights reserved.
Authors & Co-Authors
Kiechl, Stefan G.
Austria, Innsbruck
Medizinische Universitat Innsbruck
Laxton, Ross C.
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Xiao, Qingzhong
United Kingdom, London
Barts and the London School of Medicine and Dentistry
United Kingdom, London
King's College London
Hernesniemi, Jussi A.
Finland, Tampere
University Hospital of Tampere
Raitakari, Olli T.
Finland, Turku
Turun Yliopistollinen Keskussairaala
Kähönen, Mika A.P.
Finland, Tampere
University Hospital of Tampere
Mayosi, Bongani M.
United Kingdom, Oxford
University of Oxford
South Africa, Observatory
Groote Schuur Hospital
Jula, Antti M.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Moilanen, Leena
Finland, Kuopio
Itä-suomen Yliopisto
Willeit, Johann
Austria, Innsbruck
Medizinische Universitat Innsbruck
Watkins, Hugh C.
United Kingdom, Oxford
University of Oxford
Samani, Nilesh J.
United Kingdom, Leicester
University of Leicester
Lehtimäki, Terho J.
Finland, Tampere
University Hospital of Tampere
Keavney, Bernard D.
United Kingdom, Newcastle
Newcastle University
Xu, Qingbo
United Kingdom, London
King's College London
Ye, Shu
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Statistics
Citations: 35
Authors: 16
Affiliations: 11
Identifiers
Doi:
10.1161/ATVBAHA.110.213785
ISSN:
10795642
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Systematic review
Participants Gender
Male