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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Immunoexpression of BDNF, TrkB, and p75NTR receptors in peripheral neural lesions of the head and neck
Journal of Oral Pathology and Medicine, Volume 50, No. 5, Year 2021
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Description
Background: Brain-derived neurotrophic factor (BDNF) and neurotrophin receptors have been recognized as fundamental regulators of normal brain development, homeostasis, and plasticity. They have also been studied in the behavior of central nervous system tumors. Here, we studied the pattern of BDNF, TrkB and p75NTR immunoexpression in peripheral benign and malignant neural lesions in head and neck. Methods: This cross-sectional analytical study included 79 cases of head and neck neural lesions. Nineteen cases of traumatic neuromas (TN), 20 cases of granular cell tumors (GCT), 16 cases of neurofibromas (NF), 20 cases of schwannomas (SC), and 4 malignant peripheral nerve sheath tumor (MPNST) were submitted to immunohistochemistry with BDNF, TrkB, and p75NTR antibodies. A semi-quantitative analysis was performed. Results: The analysis of BDNF demonstrated a high percentage of positive cells in TN, GCT and SC with a decrease in cases of NF and MPNST. TrkB presented a lower significant immunoexpression in GCT in relation to the TN, NF, SC, and MPNST (P <.0001); and TN showed less percentage of positive cell compared to SC (P =.0017). Regarding p75NTR, the percentage of positive cell was significantly reduced in MPNST compared GCT (P =.009), NF (P =.0138) and SC (P =.0069). Also, a decrease in TN compared to GCT (P =.007) was observed. Conclusions: Our results showed the immunoreactivity of BDNF, TrkB, and p75NTR in head and neck peripheral neural lesions. Reduction of BDNF and p75NTR in MPNST might suggest down-regulation during the acquisition of malignant phenotype. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Authors & Co-Authors
Thieme, Stéfanie
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Leite, Amanda Almeida
Brazil, Campinas
Universidade Estadual de Campinas
Zanella, Virgílio Gonzales
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Brazil, Porto Alegre
Santa Casa Complexo Hospitalar
Fonseca, Felipe Paiva
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Mesquita, Ricardo Alves
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Vargas, P. A.
Brazil, Campinas
Universidade Estadual de Campinas
Santos, Jean Nunes
Brazil, Salvador
Universidade Federal da Bahia
Martins, Manoela Domingues
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Brazil, Porto Alegre
Santa Casa Complexo Hospitalar
Statistics
Citations: 2
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1111/jop.13145
ISSN:
09042512
Research Areas
Cancer
Study Design
Cross Sectional Study
Study Approach
Quantitative