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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Antiinflammatory sesquiterpenes from the root oil of Ferula hermonis
Phytotherapy Research, Volume 25, No. 5, Year 2011
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Description
Ferula hermonis Boiss. (Apiaceae), commonly known as 'Shilsh-el-zallouh', 'Hashishat-al-kattira' or 'The Lebanese viagra', is a small shrub that grows abundantly on the Hermon Mountain between Syria and Lebanon. The seeds and roots of this plant have long been used in the Middle East as an aphrodisiac, and for the treatment of frigidity and impotence for both men and women. The antiinflammatory properties of three major daucane esters, ferutinin (1) teferin (2) and teferidin (3), isolated from the root oil of Ferula hermonis, were assessed by the carrageenan-induced oedema model in rats. The antiinflammatory effect of both 1 and 2 was observed with a dose of 100 mg/kg, while compound 3 did not show any antiinflammatory activity; conversely it produced a significant proinflammatory effect 2 and 3 h after carrageenan injection. © 2010 John Wiley & Sons, Ltd.
Authors & Co-Authors
Geroushi, Afaf
Libya, Tripoli
University of Tripoli
Auzi, Abdurazag A.
Libya, Tripoli
University of Tripoli
Elhwuegi, Abdalla Salem
Libya, Tripoli
University of Tripoli
Elzawam, Fawzi
Libya, Tripoli
Biotechnology Research Center
Elsherif, Akram
Libya, Tripoli
Biotechnology Research Center
Nahar, Lutfun
United Kingdom, Wolverhampton
University of Wolverhampton
Sarker, Satyajit Dey
United Kingdom, Wolverhampton
University of Wolverhampton
Statistics
Citations: 44
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1002/ptr.3324
ISSN:
0951418X
e-ISSN:
10991573
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