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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Anti-inflammatory, antimicrobial and antioxidant activities of Diospyros bipindensis (Gürke) extracts and its main constituents
Journal of Ethnopharmacology, Volume 146, No. 1, Year 2013
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Description
Ethnopharmacological relevance: Diospyros bipindensis (Gürke) stem bark is used in Cameroon by Baka Pygmies for the treatment of respiratory disorders. Aim of the study: To assess the anti-inflammatory, antibacterial and antioxidant properties of constituents from the bark extracts through bioassay-guided fractionation. Materials and methods: The anti-inflammatory activity of extracts, fractions and pure compounds was assessed through the inhibition of the pro-inflammatory mediator nuclear factor-kappa B (NF-κB) transcriptional activity and nitric oxide (NO) production. DPPH, ABTS and ORAC assays were used for determining the antioxidant properties. The activity against Streptococcus pneumoniae, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Klebsiella pneumoniae, was evaluated on the basis of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by the macrodilution method. Results: The water extract showed antimicrobial activity against S. pneumoniae (MIC: 300 μg/ml) and S. pyogenes (MIC: 300 μg/ml). The dichloromethane extract efficiently inhibited NF-κB transcriptional activity and NO production and exhibited significant antioxidant activity in the ORAC assay. An interesting activity was also found against S. pneumoniae (MIC: 200 μg/ml), S. aureus (MIC: 400 μg/ml) and S. pyogenes (MIC: 200 μg/ml). The phytochemical investigation of the dichloromethane extract afforded plumbagin, canaliculatin, ismailin, betulinic acid and 4-hydroxy-5-methyl-coumarin as the main constituents. Plumbagin and ismailin were found to be responsible for the main biological activities observed. Conclusions: These results may provide a rational support for the traditional use of Diospyros bipindensis stem bark in the treatment of respiratory disorders, since the anti-inflammatory, antimicrobial and antioxidant compounds isolated from the dichloromethane extract were also present in the traditional water extract. © 2013 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Cesari, I.
Italy, Pavia
Università Degli Studi Di Pavia
Hoerlé, M.
Switzerland, Geneva
Université de Genève
Simoes-Pires, C.
Switzerland, Geneva
Université de Genève
Grisoli, P.
Italy, Pavia
Università Degli Studi Di Pavia
Queiroz, Emerson Ferreira
Switzerland, Geneva
Université de Genève
Dacarro, C.
Italy, Pavia
Università Degli Studi Di Pavia
Marcourt, Laurence
Switzerland, Geneva
Université de Genève
Moundipa, Paul Fewou
Cameroon, Yaounde
Université de Yaoundé I
Carrupt, Pierre-Alain
Switzerland, Geneva
Université de Genève
Cuendet, Muriel A.
Switzerland, Geneva
Université de Genève
Caccialanza, G.
Italy, Pavia
Università Degli Studi Di Pavia
Wolfender, Jean Luc
Switzerland, Geneva
Université de Genève
Brusotti, G.
Italy, Pavia
Università Degli Studi Di Pavia
Statistics
Citations: 26
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1016/j.jep.2012.12.041
ISSN:
03788741
e-ISSN:
18727573
Research Areas
Cancer
Environmental
Study Locations
Cameroon