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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Differential cytokine levels in adults induced by a Novel candidate TB boost vaccine, MVA85A-according to previous BCG vaccination status
Journal of Vaccines and Vaccination, Volume 3, No. 7, Year 2012
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Description
MVA85A is a candidate boost vaccine for TB. A previously reported study showed no differences in response to MVA85A in 10 BCG vaccinated (BCG+) and 11 BCG naive (BCG-) adult Gambians. Here we evaluated the effect of pre-existing plasma cytokines in both groups before and after MVA85A vaccination on the vaccine-induced immune response. Pre-vaccination levels of IL-8 were higher in BCG+ subjects, whilst MCP-1 levels were lower compared to BCG-. Following MVA85A vaccination, concentrations of IL-8, IL-18, IL-12(p70) and MCP-1 were differentially induced between BCG+ and BCG- groups. The implications of these findings depend on their role in TB pathogenesis. © 2012 Owiafe PK, et al.
Authors & Co-Authors
Owiafe, Patrick K.
Gambia, Fajara
Vaccinology Theme
Hill, Philip C.
Gambia, Fajara
Vaccinology Theme
New Zealand, Dunedin
University of Otago
Ibanga, Hannah B.
Gambia, Fajara
Vaccinology Theme
United Kingdom, Burton Upon Trent
Queen's Hospital Burton
Brookes, Roger H.
Gambia, Fajara
Vaccinology Theme
Canada, Toronto
Sanofi Pasteur
McShane, Helen
United Kingdom, Oxford
University of Oxford
Sutherland, Jayne S.
Gambia, Fajara
Vaccinology Theme
Ota, Martin Okechukwu C.
Gambia, Fajara
Vaccinology Theme
Statistics
Citations: 7
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.4172/2157-7560.1000158
Research Areas
Infectious Diseases