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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa
Journal of Immunology, Volume 182, No. 8, Year 2009
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Description
IL-9 contributes to lung inflammatory processes such as asthma, by promoting mast cell differentiation, B cell activation, eosinophilia, and mucus production by lung epithelial cells. The observation that IL-9 overexpressing mice show increased mast cell numbers in the intestinal mucosa suggests that this cytokine might also play a role in intestinal inflammation. In colons from IL-9 transgenic mice, the expression of Muc2, a major intestinal mucin gene, was up-regulated, together with that of CLCA3 chloride channel and resistin like α, which are goblet cell-associated genes. Additional IL-9 up-regulated genes were identified and included innate immunity genes such as angiogenin 4 and the PLA2g2a phospholipase A2, which are typical Paneth cell markers. Histochemical staining of Paneth cells by phloxine/tartrazine showed that IL-9 induces Paneth cell hyperplasia in Lieberkühn glands of the small intestine, and in the colonic mucosa, where this cell type is normally absent. Expression of Paneth cell markers, including angiogenin 4, PLA2g2a, and cryptdins, was induced in the colon of wild-type mice after two to four daily administrations of IL-9. By crossing IL-9 transgenic mice with IL-13 -/- mice, or by injecting IL-9 into IL-4R-/- mice, we showed that IL-13 was required for the up-regulation of these Paneth cell-specific genes by IL-9. Taken together, our data indicate that Paneth cell hyperplasia and expression of their various antimicrobial products contribute to the immune response driven by TH2 cytokines, such as IL-9 and IL-13 in the intestinal mucosa. Copyright © 2009 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Steenwinckel, Valérie
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Belgium, Brussels
De Duve Institute
Louahed, Jamila
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Belgium, Brussels
De Duve Institute
Lemaire, Muriel M.
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Belgium, Brussels
De Duve Institute
Sommereyns, Caroline
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Belgium, Brussels
De Duve Institute
Warnier, Guy
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
McKenzie, Andrew N.J.
United Kingdom, Cambridge
The Medical Research Council Laboratory of Molecular Biology
Brombacher, Frank
South Africa, Cape Town
Faculty of Health Sciences
van Snick, Jacques L.
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Belgium, Brussels
De Duve Institute
Renauld, Jean-Christophe Christophe
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Belgium, Brussels
De Duve Institute
Statistics
Citations: 111
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.4049/jimmunol.0801941
ISSN:
00221767
e-ISSN:
15506606
Research Areas
Genetics And Genomics