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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The predictive ability of pre-operative B-type natriuretic peptide in vascular patients for major adverse cardiac events: An individual patient data meta-analysis
Journal of the American College of Cardiology, Volume 58, No. 5, Year 2011
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Description
Objectives: The aims of this study were to perform an individual patient data meta-analysis of studies using B-type natriuretic peptides (BNPs) to predict the primary composite endpoint of cardiac death and nonfatal myocardial infarction (MI) within 30 days of vascular surgery and to determine: 1) the cut points for a natriuretic peptide (NP) diagnostic, optimal, and screening test; and 2) if pre-operative NPs improve the predictive accuracy of the revised cardiac risk index (RCRI). Background: NPs are independent predictors of cardiovascular events in noncardiac and vascular surgery. Their addition to clinical risk indexes may improve pre-operative risk stratification. Methods: Studies reporting the association of pre-operative NP concentrations and the primary study endpoint, post-operative major adverse cardiovascular events (defined as cardiovascular death and nonfatal MI) in vascular surgery, were identified by electronic database search. Secondary study endpoints included all-cause mortality, cardiac death, and nonfatal MI. Results: Six data sets were obtained, 5 for BNP (n = 632) and 1 for N-terminal pro-BNP (n = 218). An NP level higher than the optimal cut point was an independent predictor for the primary composite endpoint (odds ratio: 7.9; 95% confidence interval: 4.7 to 13.3). BNP cut points were 30 pg/ml for screening (95% sensitivity, 44% specificity), 116 pg/ml for optimal (highest accuracy point; 66% sensitivity, 82% specificity), and 372 pg/ml for diagnostic (32% sensitivity, 95% specificity). Subsequent to revised cardiac risk index stratification, reclassification using the optimal cut point significantly improved risk prediction in all groups (net reclassification improvement 58%, p < 0.000001), particularly in the intermediate-risk group (net reclassification improvement 84%, p < 0.001). Conclusions: Pre-operative NP levels can be used to independently predict cardiovascular events in the first 30 days after vascular surgery and to significantly improve the predictive performance of the revised cardiac risk index. © 2011 American College of Cardiology Foundation.
Authors & Co-Authors
Rodseth, Reitze Nils
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Durban
Inkosi Albert Luthuli Central Hospital
Lurati Buse, Giovanna A.L.
Switzerland, Basel
Universitätsspital Basel
Bolliger, Daniel
Switzerland, Basel
Universitätsspital Basel
Burkhart, Christoph Simon
Switzerland, Basel
Universitätsspital Basel
Cuthbertson, Brian H.
Canada, Toronto
University of Toronto
Gibson, Simon C.
United Kingdom, Glasgow
New Stobhill Hospital
Mahla, Elisabeth L.
Austria, Graz
Medizinische Universität Graz
Leibowitz, David W.
Israel, Jerusalem
Hadassah University Medical Centre
Biccard, Bruce Mclure
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Durban
Inkosi Albert Luthuli Central Hospital
Statistics
Citations: 125
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1016/j.jacc.2011.04.018
ISSN:
07351097
e-ISSN:
15583597
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Case-Control Study
Study Approach
Systematic review