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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Clinical and genomic characterization of hypervirulent Klebsiella pneumoniae (hvKp) infections via passive surveillance in Southern California, 2020–2022
Frontiers in Microbiology, Volume 13, Article 1001169, Year 2022
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Description
Hypervirulent Klebsiella pneumoniae (hvKp) is more invasive and virulent than classical K. pneumoniae, and requires specialized treatment. To raise clinical awareness, this study determined the prevalence, clinical characteristics, and genomic epidemiology of hvKp infections in Southern California (SoCal) by conducting a passive surveillance in a single large academic medical center. We report here that hvKp infections were more common than expected, accounting for 2.6% of invasive K. pneumoniae infections, and presented with a wide disease spectrum, occasionally mimicking tumors, even co-infecting a COVID-19 patient. Most infections were community acquired with no recent international travel, suggesting hvKp strains are circulating in the community. Genomic analysis revealed genetic diversity, with the K1-ST23 lineage predominating but not clonal, and multiple sequence types of K2 including a SoCal unique K2-ST66 sublineage that had been unrecognized. Our findings highlight the urgency of heightened awareness of hvKp infection in the US, the need for rapid diagnosis of hvKp, and the necessity of implementing robust surveillance programs for hvKp at the institutional or local level. © 2022 Kamau, Ranson, Tsan, Bergmann-Leitner, Garner and Yang.
Authors & Co-Authors
Kamau, Edwin
United States, Los Angeles
David Geffen School of Medicine at Ucla
Bergmann-Leitner, Elke S.
United States, Silver Spring
Walter Reed Army Institute of Research
Garner, Omai B.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Yang, Shangxin
United States, Los Angeles
David Geffen School of Medicine at Ucla
Statistics
Citations: 7
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.3389/fmicb.2022.1001169
ISSN:
1664302X
Research Areas
Covid
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study