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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension
JACC: Basic to Translational Science, Volume 5, No. 6, Year 2020
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Description
Oxidative damage is implicated in atrial fibrillation (AF), but antioxidants are ineffective therapeutically. The authors tested the hypothesis that highly reactive lipid dicarbonyl metabolites, or isolevuglandins (IsoLGs), are principal drivers of AF during hypertension. In a hypertensive murine model and stretched atriomyocytes, the dicarbonyl scavenger 2-hydroxybenzylamine (2-HOBA) prevented IsoLG adducts and preamyloid oligomers (PAOs), and AF susceptibility, whereas the ineffective analog 4-hydroxybenzylamine (4-HOBA) had minimal effect. Natriuretic peptides generated cytotoxic oligomers, a process accelerated by IsoLGs, contributing to atrial PAO formation. These findings support the concept of pre-emptively scavenging reactive downstream oxidative stress mediators as a potential therapeutic approach to prevent AF. © 2020 The Authors
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC7315188/bin/mmc1.pdf
Authors & Co-Authors
Kannankeril, Prince J.
United States, Nashville
Vanderbilt University School of Medicine
Boutaud, Olivier G.
United States, Nashville
Vanderbilt University School of Medicine
Saleh, Mohamed A.
United States, Nashville
Vanderbilt University School of Medicine
Norlander, Allison E.
United States, Nashville
Vanderbilt University School of Medicine
Loperena, Roxana
United States, Nashville
Vanderbilt University School of Medicine
Fogo, Agnes B.
United States, Nashville
Vanderbilt University School of Medicine
Amarnath, Venkataraman
United States, Nashville
Vanderbilt University School of Medicine
Davies, Sean S.
United States, Nashville
Vanderbilt University School of Medicine
Kirabo, Annet
United States, Nashville
Vanderbilt University School of Medicine
Madhur, Meena S.
United States, Nashville
Vanderbilt University School of Medicine
Harrison, David G.
United States, Nashville
Vanderbilt University School of Medicine
Statistics
Citations: 17
Authors: 11
Affiliations: 1
Identifiers
Doi:
10.1016/j.jacbts.2020.04.004
ISSN:
2452302X
Research Areas
Noncommunicable Diseases