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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking
RSC Medicinal Chemistry, Year 2023
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Description
We report a new class of carboplatin-TFO hybrid that incorporates a bifunctional alkyne-amine nucleobase monomer called AP-C3-dT that enables dual ‘click’ platinum(ii) drug conjugation and thiazole orange fluorophore coupling. Thiazole orange enhances the binding of Pt(ii)-TFO hybrids and provides an intrinsic method for monitoring triplex formation. These hybrid constructs possess increased stabilisation and crosslinking properties in comparison to earlier Pt(ii)-TFOs, and demonstrate sequence-specific binding at neutral pH. © 2023 The Royal Society of Chemistry.
Authors & Co-Authors
Klimkowski, Piotr
United Kingdom, Oxford
University of Oxford
Singleton, Daniel G.
United Kingdom, Southampton
University of Southampton
Farrell, Nicholas Patrick
United States, Richmond
Virginia Commonwealth University
El-Sagheer, Afaf Helmy
United Kingdom, Oxford
University of Oxford
United Kingdom, Southampton
University of Southampton
Egypt, Suez
Faculty of Petroleum and Mining Engineering
Brown, Tom
United Kingdom, Oxford
University of Oxford
Kellett, Andrew
Ireland, Dublin
Science Foundation Ireland
Statistics
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1039/d3md00548h
ISSN:
26328682
Research Areas
Genetics And Genomics