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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Genetics of susceptibility to malaria related phenotypes
Infection, Genetics and Evolution, Volume 9, No. 1, Year 2009
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Description
Previous studies have established a genetic component for susceptibility to malaria. Here we use a pedigree based approach, and transmission disequilibrium testing (TDT), to identify immune response genes that influence susceptibility to Plasmodium falciparum malarial phenotypes (parasite density and frequency of clinical episodes) in a Tanzanian population. Evidence for association was observed between markers in the TNF gene cluster and both the malarial phenotypes. There was weaker evidence for associations between HLA-DRB1*04, HLA-DRB1*10, and loci in the TCRBV region with parasite density. There was no evidence for association with polymorphisms in the IL10 promoter, IL1 gene cluster, or from the IL4/IL13 region. © 2008 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Carpenter, Danielle
United Kingdom, Leeds
University of Leeds
Rooth, Ingegerd B.
Tanzania, Tanga
National Institute for Medical Research Tanga
Färnert, Anna
Sweden, Stockholm
Karolinska Institutet
Abushama, Hind M.
United Kingdom, Leeds
University of Leeds
Quinnell, Rupert J.
United Kingdom, Leeds
University of Leeds
Shaw, Marie Anne
United Kingdom, Leeds
University of Leeds
Statistics
Citations: 24
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.meegid.2008.10.008
ISSN:
15671348
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study