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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Susceptibility-weighted imaging of the brain: Does gadolinium administration matter?
European Journal of Radiology, Volume 81, No. 2, Year 2012
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Description
Objective: Susceptibility-weighted MR imaging (SWI) is usually obtained without administration of intravenous gadolinium (Gd). However, it is occasionally necessary to perform SWI after Gd is injected. The effects of Gd on SWI have not been systematically examined. The aim of this prospective study was to investigate whether performing SWI after Gd would influence the diagnostic image quality, parenchymal signal and vascular enhancement. An additional aim is to suggest potential future applications for Gd-enhanced SWI. Methods: SWI was performed in 31 subjects before and after Gd administration. 17 cases were examined in a 1.5 T scanner and the remaining 14 were scanned at 3 T. The pre- and post-Gd images were analysed for signal changes in the cerebral grey matter (GM), white matter (WM) as well as for enhancement in the superficial and deep venous system. The visibility of the veins was graded on subtraction maps. Results: The Gd-enhanced images showed no image quality degradation and no significant signal intensity change in the GM and WM as compared to the pre-Gd images (p > 0.05). After Gd-administration significant enhancement of the venous sinuses was noticed (p < 0.005), while the deep and cortical veins were poorly enhanced as confirmed by the calculated subtraction maps. The results showed no significant difference at variable MRI field strengths. Conclusion: It is possible to perform SWI after Gd injection without information loss or signal change in the parenchyma. The most significant difference is the enhancement of the cerebral venous sinuses. Potential future applications are discussed. © 2010 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
El-Koussy, Marwan Mohamed
Switzerland, Bern
University of Bern
Egypt, Cairo
Faculty of Medicine
Schenk, Pascal
Switzerland, Bern
University of Bern
Kiefer, Claus
Switzerland, Bern
University of Bern
Osman, Omar M.
Egypt, Cairo
Faculty of Medicine
Mordasini, Pasquale
Switzerland, Bern
University of Bern
Ozdoba, Christoph
Switzerland, Bern
University of Bern
Schroth, Gerhard
Switzerland, Bern
University of Bern
Gönner, Friedrich
Switzerland, Bern
University of Bern
Statistics
Citations: 21
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.ejrad.2010.12.021
ISSN:
0720048X
e-ISSN:
18727727
Study Design
Cohort Study