Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Severe malarial anemia is associated with longterm neurocognitive impairment
Clinical Infectious Diseases, Volume 59, No. 3, Year 2014
Notification
URL copied to clipboard!
Description
Background. Cerebral malaria (CM) is associated with long-term neurocognitive impairment in children ≥5 years of age. No prospective studies to date have assessed neurocognitive impairment in children with CM <5 years of age, or in children with severe malarial anemia (SMA), a form of severe malaria estimated to affect as many as 5 million children annually. Methods. Children <5 years of age presenting to Mulago Hospital, Kampala, Uganda, with CM (n = 80) or SMA (n = 86) were assessed for overall cognitive ability, attention, and associative memory 1 week after discharge and 6 and 12 months later. The z scores for each domain were computed based on scores of 61 healthy community children (CC), who were also tested at enrollment and 6 and 12 months later. Groups were compared using mixed linear models, adjusted for age, weight for age, and child's education. Results. At 12 months, children with CM had lower adjusted scores than CC in cognitive ability (P < .001), attention (P = .02), and associative memory, (P = .002). Children with SMA had lower scores than CC in cognitive ability (P = .01) but not attention or associative memory. Cognitive ability scores in children with CM and SMA did not differ significantly. Conclusions. In children <5 years of age, SMA is associated with long-term impairment in cognitive ability, whereas CM is associated with additional impairment in the areas of attention and associative memory. SMA may be a major contributor to long-term neurocognitive impairment in children in sub-Saharan Africa. © The Author 2014.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4155441/bin/supp_59_3_336__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4155441/bin/supp_ciu293_ciu293supp.doc
Authors & Co-Authors
Bangirana, Paul
Uganda, Kampala
Makerere University College of Health Sciences
Opoka, Robert Opika
Uganda, Kampala
Makerere University College of Health Sciences
Boivin, Michael Joseph
United States, Grand Rapids
Msu College of Human Medicine
Idro, Richard I.
Uganda, Kampala
Makerere University College of Health Sciences
Hodges, James Steven
United States, Minneapolis
University of Minnesota Medical School
Romero, Regilda A.
United States, Minneapolis
University of Minnesota Medical School
Shapiro, Elsa G.
United States, Minneapolis
School of Public Health
John, Chandy Chiramukhathu
United States, Minneapolis
University of Minnesota Medical School
United States, Minneapolis
School of Public Health
Statistics
Citations: 108
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1093/cid/ciu293
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Mental Health
Study Design
Cohort Study
Study Locations
Uganda